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Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.
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- Omar, Bilal (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
- Liehua, Liu (author)
- Yamada, Yuchiro (author)
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- Seino, Yutaka (author)
- Marchetti, Piero (author)
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- (creator_code:org_t)
- 2014-06-18
- 2014
- English.
- In: Diabetologia. - : Springer Science and Business Media LLC. - 1432-0428 .- 0012-186X. ; 57:9, s. 1876-1883
- Journal article (peer-reviewed)
Abstract
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- Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves and inactivates glucagon-like peptide 1 (GLP-1), is a glucose-lowering strategy in type 2 diabetes. Since DPP-4 is a ubiquitously distributed enzyme, we examined whether it is expressed in islets and whether an islet effect to inhibit DPP-4 may result in stimulated insulin secretion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Omar, Bilal
- Liehua, Liu
- Yamada, Yuchiro
- Seino, Yutaka
- Marchetti, Piero
- Ahrén, Bo
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- MEDICAL AND HEALTH SCIENCES
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- Diabetologia
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