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A Central Role for ...
A Central Role for GRB10 in Regulation of Islet Function in Man.
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Prokopenko, Inga (author)
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- Poon, Wenny (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Mägi, Reedik (author)
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show more...
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- Prasad, Rashmi (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Salehi, S Albert (author)
- Lund University,Lunds universitet,Islet cell physiology,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Osmark, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Bouatia-Naji, Nabila (author)
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- Wierup, Nils (author)
- Lund University,Lunds universitet,Neuroendokrin cellbiologi,Forskargrupper vid Lunds universitet,Neuroendocrine Cell Biology,Lund University Research Groups
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- Fall, Tove (author)
- Uppsala universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Stančáková, Alena (author)
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Barker, Adam (author)
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Lagou, Vasiliki (author)
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Osmond, Clive (author)
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Xie, Weijia (author)
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Lahti, Jari (author)
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Jackson, Anne U (author)
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Cheng, Yu-Ching (author)
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Liu, Jie (author)
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O'Connell, Jeffrey R (author)
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Blomstedt, Paul A (author)
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- Fadista, Joao (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Alkayyali, Sami (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Dayeh, Tasnim (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Taneera, Jalal (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Lecoeur, Cecile (author)
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Kumar, Ashish (author)
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- Hansson, Ola (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Hansson, Karin B (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine
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- F Voight, Benjamin (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Kang, Hyun Min (author)
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Levy-Marchal, Claire (author)
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Vatin, Vincent (author)
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- Palotie, Aarno (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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Mari, Andrea (author)
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Weedon, Michael N (author)
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Loos, Ruth J F (author)
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Ong, Ken K (author)
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- Nilsson, Peter (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Isomaa, Bo (author)
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- Tuomi, Tiinamaija (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Wareham, Nicholas J (author)
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Stumvoll, Michael (author)
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Widen, Elisabeth (author)
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Lakka, Timo A (author)
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Langenberg, Claudia (author)
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Tönjes, Anke (author)
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Rauramaa, Rainer (author)
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Kuusisto, Johanna (author)
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Frayling, Timothy M (author)
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Froguel, Philippe (author)
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Walker, Mark (author)
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Eriksson, Johan G (author)
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- Ling, Charlotte (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - epigenetik,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Epigenetics
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Kovacs, Peter (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
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McCarthy, Mark I (author)
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Shuldiner, Alan R (author)
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Silver, Kristi D (author)
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Laakso, Markku (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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(creator_code:org_t)
- 2014-04-03
- 2014
- English.
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In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 10:4
- Related links:
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https://portal.resea... (primary) (free)
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http://www.ncbi.nlm....
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion in different tissues. GRB10 knock-down in human pancreatic islets showed reduced insulin and glucagon secretion, which together with changes in insulin sensitivity may explain the paradoxical reduction of glucose despite a decrease in insulin secretion. Together, these findings suggest that tissue-specific methylation and possibly imprinting of GRB10 can influence glucose metabolism and contribute to T2D pathogenesis. The data also emphasize the need in genetic studies to consider whether risk alleles are inherited from the mother or the father.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Prokopenko, Inga
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Poon, Wenny
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Mägi, Reedik
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Prasad, Rashmi
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Salehi, S Albert
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Almgren, Peter
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show more...
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Osmark, Peter
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Bouatia-Naji, Na ...
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Wierup, Nils
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Fall, Tove
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Stančáková, Alen ...
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Barker, Adam
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Lagou, Vasiliki
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Osmond, Clive
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Xie, Weijia
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Lahti, Jari
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Jackson, Anne U
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Cheng, Yu-Ching
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Liu, Jie
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O'Connell, Jeffr ...
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Blomstedt, Paul ...
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Fadista, Joao
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Alkayyali, Sami
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Dayeh, Tasnim
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Ahlqvist, Emma
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Taneera, Jalal
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Lecoeur, Cecile
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Kumar, Ashish
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Hansson, Ola
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Hansson, Karin B
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F Voight, Benjam ...
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Kang, Hyun Min
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Levy-Marchal, Cl ...
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Vatin, Vincent
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Palotie, Aarno
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Syvänen, Ann-Chr ...
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Mari, Andrea
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Weedon, Michael ...
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Loos, Ruth J F
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Ong, Ken K
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Nilsson, Peter
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Isomaa, Bo
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Tuomi, Tiinamaij ...
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Wareham, Nichola ...
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Stumvoll, Michae ...
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Widen, Elisabeth
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Lakka, Timo A
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Langenberg, Clau ...
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Tönjes, Anke
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Rauramaa, Rainer
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Kuusisto, Johann ...
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Frayling, Timoth ...
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Froguel, Philipp ...
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Walker, Mark
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Eriksson, Johan ...
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Ling, Charlotte
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Kovacs, Peter
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Ingelsson, Erik
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McCarthy, Mark I
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Shuldiner, Alan ...
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Silver, Kristi D
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Laakso, Markku
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Groop, Leif
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Lyssenko, Valeri ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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PLoS Genetics
- By the university
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Lund University
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Uppsala University