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Identification of s...
Identification of sequence variants influencing immunoglobulin levels
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- Jonsson, Stefan (author)
- deCODE Genetics
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- Sveinbjornsson, Gardar (author)
- deCODE Genetics
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- de Lapuente Portilla, Aitzkoa Lopez (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
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- Swaminathan, Bhairavi (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Plomp, Rosina (author)
- Leiden University Medical Centre
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- Dekkers, Gillian (author)
- University of Amsterdam
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- Ajore, Ram (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
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- Ali, Mina (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
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- Bentlage, Arthur E H (author)
- University of Amsterdam
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- Elmér, Evelina (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
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- Eyjolfsson, Gudmundur Ingi (author)
- Laboratory in Mjodd, Reykjavik
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- Gudjonsson, Sigurjon A. (author)
- deCODE Genetics
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- Gullberg, Urban (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Gylfason, Arnaldur (author)
- deCODE Genetics
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- Halldorsson, Bjarni V. (author)
- Reykjavik University
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- Hansson, Markus (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Myelomgruppen,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Myeloma research group,Lund University Research Groups
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- Holm, Hilma (author)
- deCODE Genetics
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- Johansson, Åsa (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Johnsson, Ellinor (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
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- Jonasdottir, Aslaug (author)
- deCODE Genetics
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- Ludviksson, Bjorn R (author)
- National University Hospital of Iceland
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- Oddsson, Asmundur (author)
- deCODE Genetics
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- Olafsson, Isleifur (author)
- National University Hospital of Iceland
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- Olafsson, Sigurgeir (author)
- deCODE Genetics
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- Sigurdardottir, Olof (author)
- University of Iceland
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- Sigurdsson, Asgeir (author)
- deCODE Genetics
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- Stefansdottir, Lilja (author)
- deCODE Genetics
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- Masson, Gisli (author)
- deCODE Genetics
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- Sulem, Patrick (author)
- deCODE Genetics
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- Wuhrer, Manfred (author)
- Leiden University Medical Centre
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- Wihlborg, Anna-Karin (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups
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- Thorleifsson, Gudmar (author)
- deCODE Genetics
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- Gudbjartsson, Daniel F. (author)
- University of Iceland
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- Thorsteinsdottir, Unnur (author)
- University of Iceland
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- Vidarsson, Gestur (author)
- University of Amsterdam
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- Jonsdottir, Ingileif (author)
- University of Iceland
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- Nilsson, Björn (author)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Hematogenomics,Forskargrupper vid Lunds universitet,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Broad Institute
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- Stefansson, Kari (author)
- University of Iceland
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(creator_code:org_t)
- 2017-06-19
- 2017
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:8, s. 1182-1191
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and influence blood cell development. Notable associations include a rare variant at RUNX3 decreasing IgA levels by shifting isoform proportions (rs188468174[C>T]: P = 8.3 × 10(-55), β = -0.90 s.d.), a rare in-frame deletion in FCGR2B abolishing IgG binding to the encoded receptor (p.Asn106del: P = 4.2 × 10(-8), β = 1.03 s.d.), four IGH locus variants influencing class switching, and ten new associations with the HLA region. Our results provide new insight into the regulation of humoral immunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Jonsson, Stefan
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Sveinbjornsson, ...
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de Lapuente Port ...
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Swaminathan, Bha ...
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Plomp, Rosina
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Dekkers, Gillian
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Ajore, Ram
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Ali, Mina
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Bentlage, Arthur ...
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Elmér, Evelina
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Eyjolfsson, Gudm ...
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Gudjonsson, Sigu ...
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Gullberg, Urban
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Gylfason, Arnald ...
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Halldorsson, Bja ...
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Hansson, Markus
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Holm, Hilma
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Johansson, Åsa
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Johnsson, Ellino ...
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Jonasdottir, Asl ...
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Ludviksson, Bjor ...
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Oddsson, Asmundu ...
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Olafsson, Isleif ...
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Olafsson, Sigurg ...
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Sigurdardottir, ...
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Sigurdsson, Asge ...
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Stefansdottir, L ...
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Masson, Gisli
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Sulem, Patrick
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Wuhrer, Manfred
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Wihlborg, Anna-K ...
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Thorleifsson, Gu ...
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Gudbjartsson, Da ...
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Thorsteinsdottir ...
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Vidarsson, Gestu ...
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Jonsdottir, Ingi ...
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Nilsson, Björn
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Stefansson, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University