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The genomic landsca...
The genomic landscape of hypodiploid acute lymphoblastic leukemia
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Holmfeldt, Linda (author)
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Wei, Lei (author)
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Diaz-Flores, Ernesto (author)
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Walsh, Michael (author)
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Zhang, Jinghui (author)
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Ding, Li (author)
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Payne-Turner, Debbie (author)
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Churchman, Michelle (author)
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- Andersson, Anna (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,MLL-rearrangerad leukemi hos spädbarn,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,The pathogenetic mechanisms behind MLL-rearranged acute leukemia in infancy,Lund University Research Groups
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Chen, Shann-Ching (author)
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McCastlain, Kelly (author)
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Becksfort, Jared (author)
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Ma, Jing (author)
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Wu, Gang (author)
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Patel, Samir N. (author)
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Heatley, Susan L. (author)
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Phillips, Letha A. (author)
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Song, Guangchun (author)
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Easton, John (author)
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Parker, Matthew (author)
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Chen, Xiang (author)
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Rusch, Michael (author)
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Boggs, Kristy (author)
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Vadodaria, Bhavin (author)
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Hedlund, Erin (author)
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Drenberg, Christina (author)
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Baker, Sharyn (author)
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Pei, Deqing (author)
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Cheng, Cheng (author)
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Huether, Robert (author)
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Lu, Charles (author)
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Fulton, Robert S. (author)
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Fulton, Lucinda L. (author)
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Tabib, Yashodhan (author)
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Dooling, David J. (author)
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Ochoa, Kerri (author)
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Minden, Mark (author)
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Lewis, Ian D. (author)
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To, L. Bik (author)
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Marlton, Paula (author)
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Roberts, Andrew W. (author)
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Raca, Gordana (author)
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Stock, Wendy (author)
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Neale, Geoffrey (author)
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Drexler, Hans G. (author)
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Dickins, Ross A. (author)
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Ellison, David W. (author)
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Shurtleff, Sheila A. (author)
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Pui, Ching-Hon (author)
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Ribeiro, Raul C. (author)
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Devidas, Meenakshi (author)
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Carroll, Andrew J. (author)
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Heerema, Nyla A. (author)
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Wood, Brent (author)
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Borowitz, Michael J. (author)
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Gastier-Foster, Julie M. (author)
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Raimondi, Susana C. (author)
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Mardis, Elaine R. (author)
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Wilson, Richard K. (author)
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Downing, James R. (author)
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Hunger, Stephen P. (author)
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Loh, Mignon L. (author)
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Mullighan, Charles G. (author)
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(creator_code:org_t)
- 2013-01-20
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:3, s. 242-252
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), a subtype of ALL characterized by aneuploidy and poor outcome, is unknown. Genomic profiling of 124 hypodiploid ALL cases, including whole-genome and exome sequencing of 40 cases, identified two subtypes that differ in the severity of aneuploidy, transcriptional profiles and submicroscopic genetic alterations. Near-haploid ALL with 24-31 chromosomes harbor alterations targeting receptor tyrosine kinase signaling and Ras signaling (71%) and the lymphoid transcription factor gene IKZF3 (encoding AIOLOS; 13%). In contrast, low-hypodiploid ALL with 32-39 chromosomes are characterized by alterations in TP53 (91.2%) that are commonly present in nontumor cells, IKZF2 (encoding HELIOS; 53%) and RB1 (41%). Both near-haploid and low-hypodiploid leukemic cells show activation of Ras-signaling and phosphoinositide 3-kinase (PI3K)-signaling pathways and are sensitive to PI3K inhibitors, indicating that these drugs should be explored as a new therapeutic strategy for this aggressive form of leukemia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Holmfeldt, Linda
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Wei, Lei
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Diaz-Flores, Ern ...
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Walsh, Michael
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Zhang, Jinghui
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Ding, Li
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show more...
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Payne-Turner, De ...
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Churchman, Miche ...
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Andersson, Anna
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Chen, Shann-Chin ...
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McCastlain, Kell ...
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Becksfort, Jared
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Ma, Jing
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Wu, Gang
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Patel, Samir N.
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Heatley, Susan L ...
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Phillips, Letha ...
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Song, Guangchun
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Easton, John
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Parker, Matthew
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Chen, Xiang
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Rusch, Michael
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Boggs, Kristy
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Vadodaria, Bhavi ...
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Hedlund, Erin
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Drenberg, Christ ...
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Baker, Sharyn
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Pei, Deqing
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Cheng, Cheng
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Huether, Robert
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Lu, Charles
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Fulton, Robert S ...
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Fulton, Lucinda ...
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Tabib, Yashodhan
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Dooling, David J ...
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Ochoa, Kerri
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Minden, Mark
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Lewis, Ian D.
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To, L. Bik
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Marlton, Paula
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Roberts, Andrew ...
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Raca, Gordana
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Stock, Wendy
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Neale, Geoffrey
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Drexler, Hans G.
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Dickins, Ross A.
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Ellison, David W ...
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Shurtleff, Sheil ...
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Pui, Ching-Hon
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Ribeiro, Raul C.
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Devidas, Meenaks ...
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Carroll, Andrew ...
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Heerema, Nyla A.
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Wood, Brent
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Borowitz, Michae ...
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Gastier-Foster, ...
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Raimondi, Susana ...
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Mardis, Elaine R ...
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Wilson, Richard ...
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Downing, James R ...
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Hunger, Stephen ...
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Loh, Mignon L.
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Mullighan, Charl ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Lund University