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t(3;21)(q22;q22) le...
t(3;21)(q22;q22) leading to truncation of the RYK gene in atypical chronic myeloid leukemia
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Micci, Francesca (author)
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- Panagopoulos, Ioannis (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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Haugom, Lisbeth (author)
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Andersen, Hege Kilen (author)
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Tjonnfjord, Geir E. (author)
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Beiske, Klaus (author)
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Heim, Sverre (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Cancer Letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 277:2, s. 205-211
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Abstract
Subject headings
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- The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with sequences from chromosome 21 including the ATP50 gene coding for a mitochondrial ATP synthase. The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- RYK
- Fusion gene
- Karyotyping
- aCML
- ATP50
Publication and Content Type
- art (subject category)
- ref (subject category)
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