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Tenascins are assoc...
Tenascins are associated with lipid rafts isolated from mouse brain
- Article/chapterEnglish2002
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LIBRIS-ID:oai:lup.lub.lu.se:6b105584-7984-4dd9-bd06-95c3a471e99a
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https://lup.lub.lu.se/record/335286URI
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https://doi.org/10.1016/S0006-291X(02)00520-XDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Lipid rafts are microdomains of the plasma membrane which are enriched in glycosphingolipids and specific proteins. The reported interactions of several raft-associated proteins (such as, e.g., F3) with tenascin C and tenascin R prompted us to consider that these oligomeric multidomain glycoproteins of the extracellular matrix (ECM) could associate with rafts. Here, we show punctate immunocytochemical distributions of tenascin C (TN-C) and tenascin R (TN-R) at the membrane surface of neural cells resembling the pattern reported for raft-associated proteins. Moreover, cholesterol depletion with methyl-beta-cyclodextrin reduced the punctate surface staining of TN-C. Consistently, TN-C was associated with lipid rafts of neonatal mouse brain according to sucrose density gradient centrifugation experiments. Furthermore, TN-R was also found in rafts prepared from myelin of adult mice. Thus, brain-derived tenascins are able to associate with lipid rafts. (C) 2002 Elsevier Science (USA). All rights reserved.
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Baader, SL
(author)
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Franken, S
(author)
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Pesheva, P
(author)
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Schilling, K
(author)
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Rauch, UweLund University,Lunds universitet,Kärlväggsbiologi,Forskargrupper vid Lunds universitet,Vessel Wall Biology,Lund University Research Groups(Swepub:lu)pat-ura
(author)
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Gieselmann, V
(author)
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KärlväggsbiologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
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In:Biochemical and Biophysical Research Communications294:3, s. 742-7471090-2104
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