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Deciphering the 8q2...
Deciphering the 8q24.21 association for glioma
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Enciso-Mora, Victor (author)
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Hosking, Fay J. (author)
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Kinnersley, Ben (author)
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Wang, Yufei (author)
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Shete, Sanjay (author)
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Zelenika, Diana (author)
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Broderick, Peter (author)
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Idbaih, Ahmed (author)
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Delattre, Jean-Yves (author)
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Hoang-Xuan, Khe (author)
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Marie, Yannick (author)
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Di Stefano, Anna Luisa (author)
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Labussiere, Marianne (author)
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Dobbins, Sara (author)
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Boisselier, Blandine (author)
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Ciccarino, Pietro (author)
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Rossetto, Marta (author)
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Armstrong, Georgina (author)
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Liu, Yanhong (author)
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Gousias, Konstantinos (author)
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Schramm, Johannes (author)
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Lau, Ching (author)
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Hepworth, Sarah J. (author)
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Strauch, Konstantin (author)
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Mueller-Nurasyid, Martina (author)
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Schreiber, Stefan (author)
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Franke, Andre (author)
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Moebus, Susanne (author)
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Eisele, Lewin (author)
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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Tomlinson, Ian P. (author)
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Swerdlow, Anthony (author)
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Lathrop, Mark (author)
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Simon, Matthias (author)
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Bondy, Melissa (author)
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Sanson, Marc (author)
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Houlston, Richard S. (author)
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(creator_code:org_t)
- 2013-02-11
- 2013
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 22:11, s. 2293-2302
- Related links:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequencing data generated on 253 individuals. Analysis revealed an imputed low-frequency SNP rs55705857 (P = 2.24 x 10(-38)) which was sufficient to fully capture the 8q24.21 association. Analysis by glioma subtype showed the association with rs55705857 confined to non-glioblastoma multiforme (non-GBM) tumours (P = 1.07 x 10(-67)). Validation of the non-GBM association was shown in three additional datasets (625 non-GBM cases, 2412 controls; P = 1.41 x 10(-28)). In the pooled analysis, the odds ratio for low-grade glioma associated with rs55705857 was 4.3 (P = 2.31 x 10(-94)). rs55705857 maps to a highly evolutionarily conserved sequence within the long non-coding RNA CCDC26 raising the possibility of direct functionality. These data provide additional insights into the aetiological basis of glioma development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Enciso-Mora, Vic ...
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Hosking, Fay J.
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Kinnersley, Ben
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Wang, Yufei
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Shete, Sanjay
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Zelenika, Diana
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show more...
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Broderick, Peter
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Idbaih, Ahmed
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Delattre, Jean-Y ...
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Hoang-Xuan, Khe
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Marie, Yannick
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Di Stefano, Anna ...
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Labussiere, Mari ...
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Dobbins, Sara
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Boisselier, Blan ...
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Ciccarino, Pietr ...
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Rossetto, Marta
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Armstrong, Georg ...
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Liu, Yanhong
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Gousias, Konstan ...
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Schramm, Johanne ...
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Lau, Ching
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Hepworth, Sarah ...
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Strauch, Konstan ...
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Mueller-Nurasyid ...
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Schreiber, Stefa ...
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Franke, Andre
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Moebus, Susanne
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Eisele, Lewin
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Försti, Asta
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Hemminki, Kari
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Tomlinson, Ian P ...
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Swerdlow, Anthon ...
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Lathrop, Mark
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Simon, Matthias
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Bondy, Melissa
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Sanson, Marc
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Houlston, Richar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Human Molecular ...
- By the university
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Lund University