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Genome-wide associa...
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
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Bellenguez, Celine (author)
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Bevan, Steve (author)
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Gschwendtner, Andreas (author)
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show more...
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Spencer, Chris C. A. (author)
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Burgess, Annette I. (author)
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Pirinen, Matti (author)
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Jackson, Caroline A. (author)
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Traylor, Matthew (author)
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Strange, Amy (author)
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Su, Zhan (author)
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Band, Gavin (author)
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Syme, Paul D. (author)
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Malik, Rainer (author)
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Pera, Joanna (author)
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- Norrving, Bo (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Lemmens, Robin (author)
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Freeman, Colin (author)
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Schanz, Renata (author)
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James, Tom (author)
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Poole, Deborah (author)
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Murphy, Lee (author)
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Segal, Helen (author)
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Cortellini, Lynelle (author)
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Cheng, Yu-Ching (author)
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Woo, Daniel (author)
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Nalls, Michael A. (author)
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Mueller-Myhsok, Bertram (author)
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Meisinger, Christa (author)
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Seedorf, Udo (author)
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Ross-Adams, Helen (author)
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Boonen, Steven (author)
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Wloch-Kopec, Dorota (author)
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Valant, Valerie (author)
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Slark, Julia (author)
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Furie, Karen (author)
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- Delavaran, Hossein (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Langford, Cordelia (author)
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Deloukas, Panos (author)
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Edkins, Sarah (author)
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Hunt, Sarah (author)
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Gray, Emma (author)
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Dronov, Serge (author)
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Peltonen, Leena (author)
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Gretarsdottir, Solveig (author)
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Thorleifsson, Gudmar (author)
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Thorsteinsdottir, Unnur (author)
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Stefansson, Kari (author)
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Boncoraglio, Giorgio B. (author)
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Parati, Eugenio A. (author)
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Attia, John (author)
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Holliday, Elizabeth (author)
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Levi, Chris (author)
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Franzosi, Maria-Grazia (author)
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Goel, Anuj (author)
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Helgadottir, Anna (author)
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Blackwell, Jenefer M. (author)
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Bramon, Elvira (author)
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Brown, Matthew A. (author)
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Casas, Juan P. (author)
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Corvin, Aiden (author)
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Duncanson, Audrey (author)
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Jankowski, Janusz (author)
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Mathew, Christopher G. (author)
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Palmer, Colin N. A. (author)
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Plomin, Robert (author)
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Rautanen, Anna (author)
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Sawcer, Stephen J. (author)
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Trembath, Richard C. (author)
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Viswanathan, Ananth C. (author)
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Wood, Nicholas W. (author)
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Worrall, Bradford B. (author)
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Kittner, Steven J. (author)
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Mitchell, Braxton D. (author)
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Kissela, Brett (author)
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Meschia, James F. (author)
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Thijs, Vincent (author)
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- Lindgren, Arne (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Macleod, Mary Joan (author)
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Slowik, Agnieszka (author)
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Walters, Matthew (author)
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Rosand, Jonathan (author)
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Sharma, Pankaj (author)
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Farrall, Martin (author)
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Sudlow, Cathie L. M. (author)
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Rothwell, Peter M. (author)
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Dichgans, Martin (author)
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Donnelly, Peter (author)
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Markus, Hugh S. (author)
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(creator_code:org_t)
- 2012-02-05
- 2012
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:3, s. 141-328
- Related links:
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http://dx.doi.org/10...
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https://www.pure.ed....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Bellenguez, Celi ...
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Bevan, Steve
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Gschwendtner, An ...
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Spencer, Chris C ...
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Burgess, Annette ...
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Pirinen, Matti
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show more...
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Jackson, Carolin ...
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Traylor, Matthew
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Strange, Amy
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Su, Zhan
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Band, Gavin
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Syme, Paul D.
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Malik, Rainer
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Pera, Joanna
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Norrving, Bo
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Lemmens, Robin
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Freeman, Colin
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Schanz, Renata
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James, Tom
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Poole, Deborah
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Murphy, Lee
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Segal, Helen
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Cortellini, Lyne ...
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Cheng, Yu-Ching
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Woo, Daniel
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Nalls, Michael A ...
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Mueller-Myhsok, ...
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Meisinger, Chris ...
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Seedorf, Udo
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Ross-Adams, Hele ...
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Boonen, Steven
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Wloch-Kopec, Dor ...
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Valant, Valerie
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Slark, Julia
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Furie, Karen
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Delavaran, Hosse ...
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Langford, Cordel ...
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Deloukas, Panos
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Edkins, Sarah
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Hunt, Sarah
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Gray, Emma
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Dronov, Serge
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Peltonen, Leena
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Gretarsdottir, S ...
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Thorleifsson, Gu ...
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Thorsteinsdottir ...
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Stefansson, Kari
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Boncoraglio, Gio ...
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Parati, Eugenio ...
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Attia, John
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Holliday, Elizab ...
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Levi, Chris
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Franzosi, Maria- ...
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Goel, Anuj
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Helgadottir, Ann ...
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Blackwell, Jenef ...
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Bramon, Elvira
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Brown, Matthew A ...
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Casas, Juan P.
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Corvin, Aiden
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Duncanson, Audre ...
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Jankowski, Janus ...
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Mathew, Christop ...
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Palmer, Colin N. ...
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Plomin, Robert
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Rautanen, Anna
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Sawcer, Stephen ...
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Trembath, Richar ...
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Viswanathan, Ana ...
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Wood, Nicholas W ...
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Worrall, Bradfor ...
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Kittner, Steven ...
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Mitchell, Braxto ...
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Kissela, Brett
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Meschia, James F ...
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Thijs, Vincent
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Lindgren, Arne
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Macleod, Mary Jo ...
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Slowik, Agnieszk ...
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Walters, Matthew
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Rosand, Jonathan
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Sharma, Pankaj
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Farrall, Martin
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Sudlow, Cathie L ...
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Rothwell, Peter ...
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Dichgans, Martin
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Donnelly, Peter
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Markus, Hugh S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Nature Genetics
- By the university
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Lund University