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Sökning: onr:"swepub:oai:lup.lub.lu.se:bba07c02-b3a6-457f-b691-61417c54ca63" > Effects of DPP-4 in...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003857naa a2200481 4500
001oai:lup.lub.lu.se:bba07c02-b3a6-457f-b691-61417c54ca63
003SwePub
008170120s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/bba07c02-b3a6-457f-b691-61417c54ca632 URI
0247 a https://doi.org/10.1111/dom.128172 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Yabe, Daisukeu Kobe university4 aut
2451 0a Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes : A randomized, open-label, 2-arm parallel comparative, exploratory trial
264 c 2016-11-29
264 1b Wiley,c 2017
520 a Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory hormone responses to hypoglycaemia were evaluated and compared with those of the GLP-1 receptor agonist liraglutide in a multi-centre, randomized, open-label, 2-arm parallel comparative, exploratory trial. Three-step hypoglycaemic clamp glucose tests preceded by meal tolerance tests were performed before and after 2-week treatment with the drugs. Glucagon levels were increased during the hypoglycaemic clamp test at 2.5mmol/L. This increase was similar in the linagliptin and liraglutide groups, both before and after the 2-week treatment. Changes in other counter-regulatory hormones (ie, growth hormone, cortisol, epinephrine and norepinephrine) were also similar between the groups, but were suppressed substantially after 2-week treatment compared to baseline. In conclusion, we confirmed that the glucagon response to hypoglycaemia was not affected by linagliptin or liraglutide treatment in Japanese individuals with T2D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a GLP-1 receptor agonist
653 a DPP-4 inhibitor
653 a Glucagon response
653 a Hypoglycaemia
653 a Sympatho-adrenal response
7001 a Eto, Takashiu Hakata Clinic4 aut
7001 a Shiramoto, Masanariu Hakata Clinic4 aut
7001 a Irie, Shinu Hakata Clinic4 aut
7001 a Murotani, Kentau Aichi Medical University4 aut
7001 a Seino, Yusukeu Nagoya University4 aut
7001 a Kuwata, Hitoshiu Kansai Electric Power Medical Research Institute (KEPMRI)4 aut
7001 a Kurose, Takeshiu Kansai Electric Power Medical Research Institute (KEPMRI)4 aut
7001 a Seino, Susumuu Kobe university4 aut
7001 a Ahrén, Bou Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-bah
7001 a Seino, Yutakau Kansai Electric Power Medical Research Institute (KEPMRI)4 aut
7102 a Kobe universityb Hakata Clinic4 org
7730 t Diabetes, Obesity and Metabolismd : Wileyg 19:3, s. 442-447q 19:3<442-447x 1462-8902
8564 u http://dx.doi.org/10.1111/dom.12817x freey FULLTEXT
8564 u https://doi.org/10.1111/dom.12817
8564 8u https://lup.lub.lu.se/record/bba07c02-b3a6-457f-b691-61417c54ca63
8564 8u https://doi.org/10.1111/dom.12817

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