Search: onr:"swepub:oai:lup.lub.lu.se:cbafae10-219c-405d-af37-70132b510922" >
Nonandrogenic anabo...
Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data
-
- Swiecicka, Agnieszka (author)
- University of Manchester
-
- Lunt, Mark (author)
- University of Manchester
-
- Ahern, Tomás (author)
- University of Manchester
-
show more...
-
- O'Neill, Terence W. (author)
- National Health Service Trust, NHS England,University of Manchester
-
- Bartfai, György (author)
- University of Szeged
-
- Casanueva, Felipe (author)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
-
- Forti, Gianni (author)
- University of Florence
-
- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
-
- Han, Thang S (author)
- Royal Holloway University of London
-
- Lean, Michael E J (author)
- University of Glasgow
-
- Pendleton, Neil (author)
- University of Manchester
-
- Punab, Margus (author)
- Tartu University Hospital
-
- Slowikowska-Hilczer, Jolanta (author)
- Medical University of Lodz
-
- Vanderschueren, Dirk (author)
- Catholic University of Leuven
-
- Huhtaniemi, Ilpo T. (author)
- University of Turku,Imperial College London
-
- Wu, Frederick C W (author)
- University of Manchester
-
- Rutter, Martin K. (author)
- Great Ormond Street Hospital,University of Manchester
-
show less...
-
(creator_code:org_t)
-
- 2017-05-09
- 2017
- English 9 s.
-
In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 102:8, s. 2798-2806
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://academic.oup...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men >70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Swiecicka, Agnie ...
-
Lunt, Mark
-
Ahern, Tomás
-
O'Neill, Terence ...
-
Bartfai, György
-
Casanueva, Felip ...
-
show more...
-
Forti, Gianni
-
Giwercman, Aleks ...
-
Han, Thang S
-
Lean, Michael E ...
-
Pendleton, Neil
-
Punab, Margus
-
Slowikowska-Hilc ...
-
Vanderschueren, ...
-
Huhtaniemi, Ilpo ...
-
Wu, Frederick C ...
-
Rutter, Martin K ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Journal of Clini ...
- By the university
-
Lund University