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  • Swiecicka, AgnieszkaUniversity of Manchester (author)

Nonandrogenic anabolic hormones predict risk of frailty : European male ageing study prospective data

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-05-09
  • The Endocrine Society,2017
  • 9 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:cbafae10-219c-405d-af37-70132b510922
  • https://lup.lub.lu.se/record/cbafae10-219c-405d-af37-70132b510922URI
  • https://doi.org/10.1210/jc.2017-00090DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Context: Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective: To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting: A 4.3-year prospective observational study of community-dwelling men participating in the European Male Ageing Study. Participants: Men (n = 3369) aged 40 to 79 years from eight European centers. Main Outcome Measures: Frailty status was determined using frailty phenotype (FP; n = 2114) and frailty index (FI; n = 2444). Analysis: Regression models assessed relationships between baseline levels of insulinlike growth factor 1 (IGF-1), its binding protein 3 (IGFBP-3), dehydroepiandrosterone sulfate (DHEA-S), 25-hydroxyvitamin D (25OHD), and parathyroid hormone (PTH), with changes in frailty status (worsening or improving frailty). Results: The risk of worsening FP and FI decreased with 1 standard deviation higher IGF-1, IGFBP-3, and 25OHD in models adjusted for age, body mass index, center, and baseline frailty [IGF-1: odds ratio (OR) for worsening FP, 0.82 (0.73, 0.93), percentage change in FI, -3.7% (-6.0, -1.5); IGFBP-3: 0.84 (0.75, 0.95), -4.2% (-6.4, -2.0); 25OHD: 0.84 (0.75, 0.95); -4.4%, (-6.7, -2.0)]. Relationships between IGF-1 and FI were attenuated after adjusting for IGFBP-3. Higher DHEA-S was associated with a lower risk of worsening FP only in men >70 years old [OR, 0.57 (0.35, 0.92)]. PTH was unrelated to change in frailty status. Conclusions: These longitudinal data confirm the associations between nonandrogenic anabolic hormones and the changes in frailty status. Interventional studies are needed to establish causality and determine therapeutic implications.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Lunt, MarkUniversity of Manchester (author)
  • Ahern, TomásUniversity of Manchester (author)
  • O'Neill, Terence W.National Health Service Trust, NHS England,University of Manchester (author)
  • Bartfai, GyörgyUniversity of Szeged (author)
  • Casanueva, FelipeCIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN) (author)
  • Forti, GianniUniversity of Florence (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi (author)
  • Han, Thang SRoyal Holloway University of London (author)
  • Lean, Michael E JUniversity of Glasgow (author)
  • Pendleton, NeilUniversity of Manchester (author)
  • Punab, MargusTartu University Hospital (author)
  • Slowikowska-Hilczer, JolantaMedical University of Lodz (author)
  • Vanderschueren, DirkCatholic University of Leuven (author)
  • Huhtaniemi, Ilpo T.University of Turku,Imperial College London (author)
  • Wu, Frederick C WUniversity of Manchester (author)
  • Rutter, Martin K.Great Ormond Street Hospital,University of Manchester (author)
  • University of ManchesterNational Health Service Trust, NHS England (creator_code:org_t)
  • EMAS Study Group

Related titles

  • In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society102:8, s. 2798-28060021-972X1945-7197

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