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Hepcidin levels and...
Hepcidin levels and gastric cancer risk in the EPIC-EurGast study
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- Jakszyn, Paula (author)
- Bellvitge Biomedical Research Institute
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- Fonseca-Nunes, Ana (author)
- Bellvitge Biomedical Research Institute
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- Lujan-Barroso, Leila (author)
- Bellvitge Biomedical Research Institute,University of Barcelona
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- Aranda, Núria (author)
- Rovira i Virgili University (URV)
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- Tous, Mónica (author)
- Rovira i Virgili University (URV)
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- Arija, Victoria (author)
- Rovira i Virgili University (URV)
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- Cross, Amanda (author)
- Imperial College London
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- Bueno-De-Mesquita, Bas H. (author)
- National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht
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- Weiderpass, Elisabete (author)
- Karolinska Institutet,Karolinska Institute,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Sjöberg, Klas (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Tumino, Rosario (author)
- Civic and M.P Arezzo Hospital
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- Palli, Domenico (author)
- Cancer Research and Prevention Institute (ISPO)
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- Ricceri, Fulvio (author)
- Regional Health Service
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- Fasanelli, Francesca (author)
- Regional Health Service
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- Krogh, Vittorio (author)
- Istituto Nazionale dei Tumori
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- Mattiello, Amalia (author)
- University of Naples Federico II
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- Jenab, Mazda (author)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc (author)
- International Agency for Research on Cancer, World Health Organization
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- Perez-Cornago, Aurora (author)
- University of Oxford
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- Khaw, Kay Tee (author)
- University of Cambridge
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Olsen, Anja (author)
- Danish Cancer Society
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- Overvad, Kim (author)
- Aarhus University
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Peppa, Eleni (author)
- Hellenic Health Foundation, Athens
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- Vasilopoulou, Effie (author)
- National and Kapodistrian University of Athens
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- Boeing, Heiner (author)
- German Institute of Human Nutrition
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- Sánchez-Cantalejo, Emilio (author)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Huerta, José María (author)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Dorronsoro,, Miren (author)
- Basque Regional Health Department,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
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- Barricarte, Aurelio (author)
- Health Research Institute of Navarra (IDISNA),Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),Basque Regional Health Department
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- Quirós, José Maria (author)
- Public Health Directorate,Health Research Institute of Navarra (IDISNA),Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),Basque Regional Health Department
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- Peeters, Petra H (author)
- University Medical Center Utrecht,Imperial College London
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- Agudo, Antonio (author)
- Bellvitge Biomedical Research Institute
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Kuhn, T (author)
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(creator_code:org_t)
- 2017-06-21
- 2017
- English 7 s.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 141:5, s. 945-951
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Abstract
Subject headings
Close
- Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93–0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- cohort study
- gastric cancer
- hepcidin
- iron homeostasis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Jakszyn, Paula
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Fonseca-Nunes, A ...
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Lujan-Barroso, L ...
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Aranda, Núria
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Tous, Mónica
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Arija, Victoria
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show more...
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Cross, Amanda
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Bueno-De-Mesquit ...
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Weiderpass, Elis ...
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Kaaks, Rudolf
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Sjöberg, Klas
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Ohlsson, Bodil
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Tumino, Rosario
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Palli, Domenico
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Ricceri, Fulvio
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Fasanelli, Franc ...
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Krogh, Vittorio
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Mattiello, Amali ...
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Jenab, Mazda
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Gunter, Marc
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Perez-Cornago, A ...
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Khaw, Kay Tee
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Trichopoulou, An ...
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Peppa, Eleni
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Vasilopoulou, Ef ...
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Boeing, Heiner
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Sánchez-Cantalej ...
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Huerta, José Mar ...
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Dorronsoro,, Mir ...
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Barricarte, Aure ...
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Quirós, José Mar ...
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Peeters, Petra H
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Agudo, Antonio
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Kuhn, T
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Karolinska Institutet