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Genome-wide associa...
Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility
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- Sud, Amit (author)
- Institute of Cancer Research London
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- Thomsen, Hauke (author)
- German Cancer Research Centre
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- Law, Philip J (author)
- Institute of Cancer Research London
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- Försti, Asta (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Filho, Miguel Inacio da Silva (author)
- German Cancer Research Centre
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- Holroyd, Amy (author)
- Institute of Cancer Research London
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- Broderick, Peter (author)
- Institute of Cancer Research London
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- Orlando, Giulia (author)
- Institute of Cancer Research London
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- Lenive, Oleg (author)
- Institute of Cancer Research London
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- Wright, Lauren (author)
- Institute of Cancer Research London
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- Cooke, Rosie (author)
- Institute of Cancer Research London
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- Easton, Douglas (author)
- University of Cambridge
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- Pharoah, Paul (author)
- University of Cambridge
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- Dunning, Alison (author)
- University of Cambridge
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- Peto, Julian (author)
- London School of Hygiene and Tropical Medicine
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- Canzian, Federico (author)
- German Cancer Research Centre
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- Eeles, Rosalind (author)
- Royal Marsden NHS Foundation Trust
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- Kote-Jarai, ZSofia (author)
- Institute of Cancer Research London
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- Muir, Kenneth (author)
- University of Warwick
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- Pashayan, Nora (author)
- University College London
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- Hoffmann, Per (author)
- University of Bonn
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- Nöthen, Markus M (author)
- University of Bonn
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- Jöckel, Karl-Heinz (author)
- University of Duisburg-Essen
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- Strandmann, Elke Pogge von (author)
- University Hospital of Cologne
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- Lightfoot, Tracy (author)
- University of York
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- Kane, Eleanor (author)
- University of York
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- Roman, Eve (author)
- University of York
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- Lake, Annette (author)
- University of Glasgow
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- Montgomery, Dorothy (author)
- University of Glasgow
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- Jarrett, Ruth F (author)
- University of Glasgow
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- Swerdlow, Anthony J (author)
- Institute of Cancer Research London
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- Engert, Andreas (author)
- University Hospital of Cologne
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- Orr, Nick (author)
- Institute of Cancer Research London
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- Hemminki, Kari (author)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
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- Houlston, Richard S (author)
- Institute of Cancer Research London
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(creator_code:org_t)
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- 2017-12-01
- 2017
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1, s. 1892-1892
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Journal Article
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Sud, Amit
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Thomsen, Hauke
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Law, Philip J
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Försti, Asta
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Filho, Miguel In ...
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Holroyd, Amy
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show more...
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Broderick, Peter
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Orlando, Giulia
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Lenive, Oleg
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Wright, Lauren
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Cooke, Rosie
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Easton, Douglas
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Pharoah, Paul
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Dunning, Alison
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Peto, Julian
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Canzian, Federic ...
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Eeles, Rosalind
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Kote-Jarai, ZSof ...
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Muir, Kenneth
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Pashayan, Nora
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Hoffmann, Per
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Nöthen, Markus M
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Jöckel, Karl-Hei ...
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Strandmann, Elke ...
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Lightfoot, Tracy
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Kane, Eleanor
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Roman, Eve
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Lake, Annette
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Montgomery, Doro ...
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Jarrett, Ruth F
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Swerdlow, Anthon ...
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Engert, Andreas
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Orr, Nick
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Hemminki, Kari
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Houlston, Richar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University
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Uppsala University