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Adult-onset type 1 ...
Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients
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- Ren, Wenqian (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Yang, Daizhi (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Jiang, Ziyu (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Xian, Yingxin (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Huang, Qianwen (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Luo, Sihui (author)
- University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
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- Zheng, Xueying (author)
- University of Science and Technology of China
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- Yan, Jinhua (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Xu, Wen (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Yao, Bin (author)
- Third Affiliated Hospital of Sun Yat‐sen University
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- Wang, Cong Yi (author)
- Huazhong University of Science and Technology
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- Bei, Jin Xin (author)
- Sun Yat-sen University
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- Groop, Leif (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,University of Science and Technology of China
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- Noble, Janelle A. (author)
- Children's Hospital Oakland Research Institute
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- Weng, Jianping (author)
- University of Science and Technology of China,Third Affiliated Hospital of Sun Yat‐sen University
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(creator_code:org_t)
- 2020-06-21
- 2021
- English.
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In: Diabetes/Metabolism Research and Reviews. - : Wiley. - 1520-7552 .- 1520-7560. ; 37:1
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Abstract
Subject headings
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- Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patients with classical type 1 diabetes (100 childhood-onset and 114 adult-onset) were selected for HLA DR and DQ genotyping by next-generation sequencing. Results: Adult-onset patients were characterized by longer duration of symptoms before diagnosis, lower frequency of DKA at disease onset, less frequent autoantibody positivity, higher serum C-peptide concentrations, and better glycemic control. These findings were replicated in the restricted cohort of 214 patients with classical type 1 diabetes. Compared with childhood-onset patients, adult-onset patients had a lower frequency of the DR9 haplotype, as well as lower frequency of high-risk DR3/DR4 and DR3/DR9 genotypes, but higher frequency of DR3/DR3 genotype and DR3/X, DR4/X or DR9/X (X, non-risk) genotypes. Conclusions: Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- adult onset diabetes
- age of diabetes onset
- clinical characteristics
- genetics
- HLA typing
- type 1 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ren, Wenqian
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Yang, Daizhi
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Jiang, Ziyu
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Xian, Yingxin
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Huang, Qianwen
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Luo, Sihui
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show more...
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Zheng, Xueying
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Yan, Jinhua
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Xu, Wen
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Yao, Bin
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Wang, Cong Yi
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Bei, Jin Xin
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Groop, Leif
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Noble, Janelle A ...
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Weng, Jianping
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes/Metabol ...
- By the university
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Lund University