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The role of topical...
The role of topical timolol in the treatment of infantile hemangiomas : A systematic review and meta-analysis
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- Khan, Maham (author)
- Guy's and St Thomas' NHS Foundation Trust
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- Boyce, Aaron (author)
- Guy's and St Thomas' NHS Foundation Trust,King's College London
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- Prieto-Merino, David (author)
- London School of Hygiene and Tropical Medicine,University of Murcia
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- Svensson, Åke (author)
- Lund University,Lunds universitet,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups
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- Wedgeworth, Emma (author)
- King's College London,Guy's and St Thomas' NHS Foundation Trust
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- Flohr, Carsten (author)
- King's College London,Guy's and St Thomas' NHS Foundation Trust
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(creator_code:org_t)
- Medical Journals Sweden AB, 2017
- 2017
- English 5 s.
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In: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555. ; 97:10, s. 1167-1171
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Abstract
Subject headings
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- To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not been reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07–15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- Beta-blocker
- Infantile hemangioma
- Timolol
Publication and Content Type
- for (subject category)
- ref (subject category)
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