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Partially methylate...
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
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- Brinkman, Arie B. (author)
- Radboud University Nijmegen
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- Nik-Zainal, Serena (author)
- Wellcome Trust Sanger Institute,University of Cambridge
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- Simmer, Femke (author)
- Radboud University Nijmegen
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- Rodríguez-González, F. Germán (author)
- Erasmus University Medical Center
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- Smid, Marcel (author)
- Erasmus University Medical Center
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- Alexandrov, Ludmil B. (author)
- Los Alamos National Laboratory,Wellcome Trust Sanger Institute
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- Butler, Adam (author)
- Wellcome Trust Sanger Institute
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- Martin, Sancha (author)
- Wellcome Trust Sanger Institute
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- Davies, Helen (author)
- Wellcome Trust Sanger Institute
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- Glodzik, Dominik (author)
- Wellcome Trust Sanger Institute
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- Zou, Xueqing (author)
- Wellcome Trust Sanger Institute
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- Ramakrishna, Manasa (author)
- Wellcome Trust Sanger Institute
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Ringnér, Markus (author)
- Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science
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- Sieuwerts, Anieta (author)
- Erasmus University Medical Center
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- Ferrari, Anthony (author)
- Centre Léon Bérard
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- Morganella, Sandro (author)
- Wellcome Trust
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- Fleischer, Thomas (author)
- Norwegian Radium Hospital
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- Kristensen, Vessela (author)
- University of Oslo,Akershus University Hospital,Norwegian Radium Hospital
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- Gut, Marta (author)
- University of Barcelona
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- van de Vijver, Marc J. (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Børresen-Dale, Anne Lise (author)
- Norwegian Radium Hospital,University of Oslo
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- Richardson, Andrea L. (author)
- Dana-Farber Cancer Institute,Brigham and Women's Hospital / Harvard Medical School
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- Thomas, Gilles (author)
- Centre Léon Bérard
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- Gut, Ivo G. (author)
- University of Barcelona
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- Martens, John W.M. (author)
- Erasmus University Medical Center
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- Foekens, John A. (author)
- Erasmus University Medical Center
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- Stratton, Michael R. (author)
- Wellcome Trust Sanger Institute
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- Stunnenberg, Hendrik G. (author)
- Radboud University Nijmegen
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(creator_code:org_t)
- 2019-04-15
- 2019
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. We comprehensively show that loss of methylation in PMDs occurs in a large fraction of the genome and represents the prime source of DNA methylation variation. PMDs are hypervariable in methylation level, size and distribution, and display elevated mutation rates. They impose intermediate DNA methylation levels incognizant of functional genomic elements including CGIs, underpinning a CGI methylator phenotype (CIMP). Repression effects on tumor suppressor genes are negligible as they are generally excluded from PMDs. The genomic distribution of PMDs reports tissue-of-origin and may represent tissue-specific silent regions which tolerate instability at the epigenetic, transcriptomic and genetic level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Brinkman, Arie B ...
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Nik-Zainal, Sere ...
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Simmer, Femke
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Rodríguez-Gonzál ...
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Smid, Marcel
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Alexandrov, Ludm ...
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show more...
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Butler, Adam
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Martin, Sancha
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Davies, Helen
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Glodzik, Dominik
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Zou, Xueqing
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Ramakrishna, Man ...
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Staaf, Johan
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Ringnér, Markus
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Sieuwerts, Aniet ...
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Ferrari, Anthony
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Morganella, Sand ...
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Fleischer, Thoma ...
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Kristensen, Vess ...
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Gut, Marta
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van de Vijver, M ...
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Børresen-Dale, A ...
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Richardson, Andr ...
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Thomas, Gilles
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Gut, Ivo G.
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Martens, John W. ...
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Foekens, John A.
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Stratton, Michae ...
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Stunnenberg, Hen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University