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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Shungin, Dmitry (author)
Umeå universitet,Umeå University,Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;,Institutionen för odontologi
Haworth, Simon (author)
University of Bristol
Divaris, Kimon (author)
University of North Carolina
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Agler, Cary S. (author)
University of North Carolina,Osaka University
Kamatani, Yoichiro (author)
RIKEN Center for Integrative Medical Sciences
Keun Lee, Myoung (author)
University of Pittsburgh
Grinde, Kelsey (author)
University of Washington
Hindy, George (author)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
Alaraudanjoki, Viivi (author)
University of Oulu
Pesonen, Paula (author)
Karolinska Institutet
Teumer, Alexander (author)
University Medicine Greifswald
Holtfreter, Birte (author)
University Medicine Greifswald
Sakaue, Saori (author)
Osaka University
Hirata, Jun (author)
Osaka University
Yu, Yau Hua (author)
Tufts University,Brigham and Women's Hospital / Harvard Medical School
Ridker, Paul M. (author)
Brigham and Women's Hospital / Harvard Medical School,Harvard University
Giulianini, Franco (author)
Brigham and Women's Hospital / Harvard Medical School
Chasman, Daniel I. (author)
Brigham and Women's Hospital / Harvard Medical School,Harvard University
Magnusson, Patrik K.E. (author)
Karolinska Institute
Sudo, Takeaki (author)
Tokyo Medical and Dental University
Okada, Yukinori (author)
Osaka University
Völker, Uwe (author)
University Medicine Greifswald
Kocher, Thomas (author)
University Medicine Greifswald
Anttonen, Vuokko (author)
University of Oulu,Oulu University Hospital
Laitala, Marja Liisa (author)
University of Oulu
Orho-Melander, Marju (author)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
Sofer, Tamar (author)
Harvard University,Brigham and Women's Hospital / Harvard Medical School
Shaffer, John R. (author)
University of Pittsburgh
Vieira, Alexandre (author)
University of Pittsburgh
Marazita, Mary L. (author)
University of Pittsburgh
Kubo, Michiaki (author)
RIKEN Center for Integrative Medical Sciences
Furuichi, Yasushi (author)
Hokkaido University
North, Kari E. (author)
University of North Carolina
Offenbacher, Steve (author)
University of North Carolina
Ingelsson, Erik (author)
Stanford University
Franks, Paul W. (author)
Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö SE-214 28, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA,Avdelningen för medicin
Timpson, Nicholas J. (author)
University of Bristol
Johansson, Ingegerd (author)
Umeå universitet,Umeå University,Institutionen för odontologi
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 (creator_code:org_t)
2019-06-24
2019
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
Related links:
http://dx.doi.org/10... (free)
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https://www.nature.c...
https://doi.org/10.1...
https://umu.diva-por... (primary) (Raw object)
https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
http://kipublication...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

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