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Familial risks of T...
Familial risks of Tourette syndrome and chronic tic disorders : a population-based cohort study
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- Mataix-Cols, David (author)
- Karolinska Institutet
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- Isomura, Kayoko (author)
- Karolinska Institutet
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- Pérez-Vigil, Ana (author)
- Karolinska Institutet
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- Chang, Zheng (author)
- Karolinska Institutet
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- Rück, Christian (author)
- Karolinska Institutet
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- Larsson, K Johan (author)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Leckman, James F (author)
- Child Study Center, Yale University, New Haven CT, USA; Department of Psychiatry, Yale University, New Haven CT, USA; Department of Pediatrics and Psychology, Yale University, New Haven CT, USA
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- Serlachius, Eva (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Karolinska Institutet
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- Lichtenstein, Paul (author)
- Karolinska Institutet
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- ISSN 2168-622X
- Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics, 2015
- 2015
- English.
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In: JAMA Psychiatry. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 2168-622X .- 2168-6238.
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Abstract
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- Importance: Chronic Tic Disorders (CTD), including Tourette Syndrome (TS), are assumed to be strongly familial and heritable. While gene-searching efforts are well underway, precise estimates of familial risk and heritability are lacking. Previous controlled family studies were small and typically conducted within specialist clinics, resulting in potential ascertainment biases. They were also underpowered to disentangle genetic from environmental factors contributing to the observed familiality. Twin studies have been either very small or based on parent-reported tics in population-based (non-clinical) twin samples. Objective: To provide unbiased estimates of familial risk and heritability of TS/CTD at the population level. Design and Setting: Population cohort, multigenerational, family study. Participants: Using a validated algorithm, we identified 4,826 individuals diagnosed with TS/CTD (76% male) in the Swedish National Patient Register between 1969-2009. Main outcome measure: Risks (Odds Ratios; OR) for TS/CTD in all biological relatives of probands, compared to relatives of unaffected individuals (matched on a 1:10 ratio) from the general population. Structural equation modeling was used to estimate the heritability of TS/CTD. Results: The risk for TS/CTD amongst relatives of TS/CTD probands increased proportionally to the degree of genetic relatedness. The risks for first-degree relatives (OR= 18.69, 95% CI 14.53-24.05) were significantly higher than for second-degree relatives (OR= 4.58, 95% CI 3.22-6.52) and third-degree relatives (OR= 3.07, 95% CI 2.08-4.51). First-degree relatives at similar genetic distances (e.g. parents, siblings, offspring) had similar risks for TS/CTD, despite different degrees of shared environment. The risks for full siblings (50% genetic similarity; OR=17.68, 95% CI 12.90-24.23) were significantly higher than that for maternal-half siblings (25% genetic similarity; OR= 4.41, 95% CI 2.24-8.67), despite similar environmental exposures. The heritability of TS/CTD was estimated to be 0.77 (95% CI 0.70-0.85). There were no differences in familial risk or heritability between male and female patients. Conclusions and relevance: TS/CTD clusters in families primarily due to genetic factors and appears to be amongst the most heritable neuropsychiatric conditions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mataix-Cols, Dav ...
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Isomura, Kayoko
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Pérez-Vigil, Ana
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Chang, Zheng
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Rück, Christian
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Larsson, K Johan
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show more...
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Leckman, James F
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Serlachius, Eva
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Larsson, Henrik, ...
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Lichtenstein, Pa ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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JAMA Psychiatry
- By the university
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Karolinska Institutet
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Örebro University