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Replicability and r...
Replicability and robustness of genome-wide-association studies for behavioral traits
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- Rietveld, CA (author)
- Erasmus University (NL)
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- Conley, D (author)
- New York University
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- Eriksson, N (author)
- 23andMe
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- Esko, T (author)
- University of Tartu
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- Medland, SE (author)
- Queensland Institute of Medical Research
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- Vinkhuyzen, AAE (author)
- University of Queensland (AU)
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- Yang, J (author)
- University of Queensland (AU),23andMe
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- Boardman, JD (author)
- University of Colorado
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- Chabris, CF (author)
- Union College (US)
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- Dawes, CT (author)
- New York University
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- Domingue, BW (author)
- University of Colorado
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- Hinds, DA (author)
- 23andMe
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- Johannesson, Magnus (author)
- Stockholm School of Economics,Handelshögskolan i Stockholm
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- Kiefer, AK (author)
- 23andMe
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- Laibson, D (author)
- Harvard University (US)
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- Magnusson, PKE (author)
- Karolinska Institutet,Karolinska Institutet (SE)
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- Mountain, JL (author)
- 23andMe
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- Oskarsson, Sven (author)
- Uppsala universitet,Statsvetenskapliga institutionen,Uppsala University (SE)
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- Rostapshova, O (author)
- Harvard University (US)
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- Teumer, A (author)
- Greifswald Medical School
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Tung, JY (author)
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- Visscher, PM (author)
- University of Queensland (AU)
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- Benjamin, DJ (author)
- Cornell University (US)
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- Cesarini, D (author)
- Center for Experimental Social Science
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- Koellinger, PD (author)
- Erasmus School of Economics (NL)
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(creator_code:org_t)
- 2014-10-06
- 2014
- English.
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In: Psychological science. - : SAGE Publications. - 1467-9280 .- 0956-7976. ; 25:11, s. 1975-1986
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Abstract
Subject headings
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- A recent genome-wide-association study of educational attainment identified three single-nucleotide polymorphisms (SNPs) whose associations, despite their small effect sizes (each R2 ≈ 0.02%), reached genome-wide significance ( p < 5 × 10−8) in a large discovery sample and were replicated in an independent sample ( p < .05). The study also reported associations between educational attainment and indices of SNPs called “polygenic scores.” In three studies, we evaluated the robustness of these findings. Study 1 showed that the associations with all three SNPs were replicated in another large ( N = 34,428) independent sample. We also found that the scores remained predictive ( R2 ≈ 2%) in regressions with stringent controls for stratification (Study 2) and in new within-family analyses (Study 3). Our results show that large and therefore well-powered genome-wide-association studies can identify replicable genetic associations with behavioral traits. The small effect sizes of individual SNPs are likely to be a major contributing factor explaining the striking contrast between our results and the disappointing replication record of most candidate-gene studies.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rietveld, CA
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Conley, D
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Eriksson, N
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Esko, T
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Medland, SE
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Vinkhuyzen, AAE
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show more...
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Yang, J
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Boardman, JD
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Chabris, CF
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Dawes, CT
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Domingue, BW
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Hinds, DA
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Johannesson, Mag ...
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Kiefer, AK
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Laibson, D
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Magnusson, PKE
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Mountain, JL
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Oskarsson, Sven
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Rostapshova, O
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Teumer, A
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Tung, JY
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Visscher, PM
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Benjamin, DJ
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Cesarini, D
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Koellinger, PD
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show less...
- About the subject
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Psychological sc ...
- By the university
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Karolinska Institutet
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Uppsala University
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Stockholm School of Economics