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Sixteen new lung fu...
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
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Artigas, MS (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Miller, S (author)
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Kheirallah, AK (author)
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Huffman, JE (author)
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Ntalla, I (author)
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Shrine, N (author)
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Obeidat, M (author)
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Trochet, H (author)
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McArdle, WL (author)
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Alves, AC (author)
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Hui, J (author)
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Zhao, JH (author)
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Joshi, PK (author)
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Teumer, A (author)
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Albrecht, E (author)
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Imboden, M (author)
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Rawal, R (author)
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Lopez, LM (author)
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Marten, J (author)
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- Enroth, Stefan (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Gyllensten
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Surakka, I (author)
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Polasek, O (author)
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Lyytikainen, LP (author)
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Granell, R (author)
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Hysi, PG (author)
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Flexeder, C (author)
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Mahajan, A (author)
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Beilby, J (author)
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Bosse, Y (author)
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Brandsma, CA (author)
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Campbell, H (author)
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Gieger, C (author)
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Glaser, S (author)
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Gonzalez, JR (author)
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Grallert, H (author)
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Hammond, CJ (author)
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Harris, SE (author)
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Hartikainen, AL (author)
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Heliovaara, M (author)
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Henderson, J (author)
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Hocking, L (author)
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Horikoshi, M (author)
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Hutri-Kahonen, N (author)
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- Ingelsson, Erik (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
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- Johansson, Åsa (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala kliniska forskningscentrum (UCR)
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Kemp, JP (author)
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Kolcic, I (author)
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Kumar, A (author)
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Lind, L (author)
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- Melen, E (author)
- Karolinska Institutet
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Musk, AW (author)
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Navarro, P (author)
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Nickle, DC (author)
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Padmanabhan, S (author)
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Raitakari, OT (author)
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Ried, JS (author)
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Ripatti, S (author)
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Schulz, H (author)
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Scott, RA (author)
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Sin, DD (author)
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Starr, JM (author)
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Vinuela, A (author)
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Volzke, H (author)
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Wild, SH (author)
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Wright, AF (author)
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Zemunik, T (author)
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Jarvis, DL (author)
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Spector, TD (author)
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Evans, DM (author)
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Lehtimaki, T (author)
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Vitart, V (author)
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Kahonen, M (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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Rudan, I (author)
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Deary, IJ (author)
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Karrasch, S (author)
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Probst-Hensch, NM (author)
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Heinrich, J (author)
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Stubbe, B (author)
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Wilson, JF (author)
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Wareham, NJ (author)
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James, AL (author)
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Morris, AP (author)
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Jarvelin, MR (author)
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Hayward, C (author)
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Sayers, I (author)
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Strachan, DP (author)
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Hall, IP (author)
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Tobin, MD (author)
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Deloukas, P (author)
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Hansell, AL (author)
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Hubbard, R (author)
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Jackson, VE (author)
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Marchini, J (author)
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Pavord, I (author)
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Thomson, NC (author)
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Zeggini, E (author)
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(creator_code:org_t)
- 2015-12-04
- 2015
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 8658-
- Related links:
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https://www.nature.c...
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https://uu.diva-port... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Artigas, MS
-
Lind, Lars
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Miller, S
-
Kheirallah, AK
-
Huffman, JE
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Ntalla, I
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show more...
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Shrine, N
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Obeidat, M
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Trochet, H
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McArdle, WL
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Alves, AC
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Hui, J
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Zhao, JH
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Joshi, PK
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Teumer, A
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Albrecht, E
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Imboden, M
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Rawal, R
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Lopez, LM
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Marten, J
-
Enroth, Stefan
-
Surakka, I
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Polasek, O
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Lyytikainen, LP
-
Granell, R
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Hysi, PG
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Flexeder, C
-
Mahajan, A
-
Beilby, J
-
Bosse, Y
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Brandsma, CA
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Campbell, H
-
Gieger, C
-
Glaser, S
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Gonzalez, JR
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Grallert, H
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Hammond, CJ
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Harris, SE
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Hartikainen, AL
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Heliovaara, M
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Henderson, J
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Hocking, L
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Horikoshi, M
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Hutri-Kahonen, N
-
Ingelsson, Erik
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Johansson, Åsa
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Kemp, JP
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Kolcic, I
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Kumar, A
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Lind, L
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Melen, E
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Musk, AW
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Navarro, P
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Nickle, DC
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Padmanabhan, S
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Raitakari, OT
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Ried, JS
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Ripatti, S
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Schulz, H
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Scott, RA
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Sin, DD
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Starr, JM
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Vinuela, A
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Volzke, H
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Wild, SH
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Wright, AF
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Zemunik, T
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Jarvis, DL
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Spector, TD
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Evans, DM
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Lehtimaki, T
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Vitart, V
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Kahonen, M
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Gyllensten, Ulf
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Rudan, I
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Deary, IJ
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Karrasch, S
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Probst-Hensch, N ...
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Heinrich, J
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Stubbe, B
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Wilson, JF
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Wareham, NJ
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James, AL
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Morris, AP
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Jarvelin, MR
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Hayward, C
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Sayers, I
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Strachan, DP
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Hall, IP
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Tobin, MD
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Deloukas, P
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Hansell, AL
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Hubbard, R
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Jackson, VE
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Marchini, J
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Pavord, I
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Thomson, NC
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Zeggini, E
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet
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Uppsala University