Search: onr:"swepub:oai:prod.swepub.kib.ki.se:138214051" >
Investigation of co...
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
-
Huckins, LM (author)
-
Hatzikotoulas, K (author)
-
Southam, L (author)
-
show more...
-
Thornton, LM (author)
-
Steinberg, J (author)
-
Aguilera-McKay, F (author)
-
Treasure, J (author)
-
Schmidt, U (author)
-
Gunasinghe, C (author)
-
Romero, A (author)
-
Curtis, C (author)
-
Rhodes, D (author)
-
Moens, J (author)
-
Kalsi, G (author)
-
Dempster, D (author)
-
Leung, R (author)
-
Keohane, A (author)
-
Burghardt, R (author)
-
Ehrlich, S (author)
-
Hebebrand, J (author)
-
Hinney, A (author)
-
Ludolph, A (author)
-
Walton, E (author)
-
Deloukas, P (author)
-
Hofman, A (author)
-
Palotie, A (author)
-
Palta, P (author)
-
van Rooij, FJA (author)
-
Stirrups, K (author)
-
Adan, R (author)
-
Boni, C (author)
-
Cone, R (author)
-
Dedoussis, G (author)
-
van Furth, E (author)
-
Gonidakis, F (author)
-
Gorwood, P (author)
-
Hudson, J (author)
-
Kaprio, J (author)
-
Kas, M (author)
-
Keski-Rahonen, A (author)
-
Kiezebrink, K (author)
-
Knudsen, GP (author)
-
Slof-Op 't Landt, MCT (author)
-
Maj, M (author)
-
Monteleone, AM (author)
-
Monteleone, P (author)
-
Raevuori, AH (author)
-
Reichborn-Kjennerud, T (author)
-
Tozzi, F (author)
-
Tsitsika, A (author)
-
van Elburg, A (author)
-
Collier, DA (author)
-
- Sullivan, PF (author)
- Karolinska Institutet
-
Breen, G (author)
-
- Bulik, CM (author)
- Karolinska Institutet
-
Zeggini, E (author)
-
show less...
-
(creator_code:org_t)
- 2017-07-25
- 2018
- English.
-
In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 23:5, s. 1169-1180
- Related links:
-
https://www.nature.c...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Huckins, LM
-
Hatzikotoulas, K
-
Southam, L
-
Thornton, LM
-
Steinberg, J
-
Aguilera-McKay, ...
-
show more...
-
Treasure, J
-
Schmidt, U
-
Gunasinghe, C
-
Romero, A
-
Curtis, C
-
Rhodes, D
-
Moens, J
-
Kalsi, G
-
Dempster, D
-
Leung, R
-
Keohane, A
-
Burghardt, R
-
Ehrlich, S
-
Hebebrand, J
-
Hinney, A
-
Ludolph, A
-
Walton, E
-
Deloukas, P
-
Hofman, A
-
Palotie, A
-
Palta, P
-
van Rooij, FJA
-
Stirrups, K
-
Adan, R
-
Boni, C
-
Cone, R
-
Dedoussis, G
-
van Furth, E
-
Gonidakis, F
-
Gorwood, P
-
Hudson, J
-
Kaprio, J
-
Kas, M
-
Keski-Rahonen, A
-
Kiezebrink, K
-
Knudsen, GP
-
Slof-Op 't Landt ...
-
Maj, M
-
Monteleone, AM
-
Monteleone, P
-
Raevuori, AH
-
Reichborn-Kjenne ...
-
Tozzi, F
-
Tsitsika, A
-
van Elburg, A
-
Collier, DA
-
Sullivan, PF
-
Breen, G
-
Bulik, CM
-
Zeggini, E
-
show less...
- Articles in the publication
-
Molecular psychi ...
- By the university
-
Karolinska Institutet