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Multi-ancestry stud...
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
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- Kilpelainen, TO (author)
- University of Copenhagen,Icahn School of Medicine at Mount Sinai
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Bentley, AR (author)
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Noordam, R (author)
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show more...
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Sung, YJ (author)
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Schwander, K (author)
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Winkler, TW (author)
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Jakupovic, H (author)
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Chasman, DI (author)
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Manning, A (author)
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Ntalla, I (author)
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Aschard, H (author)
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Brown, MR (author)
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- de las Fuentes, L (author)
- Karolinska Institutet
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Franceschini, N (author)
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Guo, XQ (author)
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Vojinovic, D (author)
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Aslibekyan, S (author)
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Feitosa, MF (author)
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- Kho, M (author)
- Karolinska Institutet
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Musani, SK (author)
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Richard, M (author)
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Wang, HM (author)
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Wang, Z (author)
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Bartz, TM (author)
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Bielak, LF (author)
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Campbell, A (author)
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Dorajoo, R (author)
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Fisher, V (author)
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- Franks, Paul (author)
- Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Harvard University
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Horimoto, ARVR (author)
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Li, CW (author)
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Lohman, KK (author)
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Marten, J (author)
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Sim, XL (author)
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Smith, AV (author)
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Tajuddin, SM (author)
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Alver, M (author)
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Amini, M (author)
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Boissel, M (author)
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Chai, JF (author)
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- Chen, X (author)
- Karolinska Institutet
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Divers, J (author)
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Evangelou, E (author)
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- Gao, C (author)
- Washington University in St. Louis
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Graff, M (author)
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Harris, SE (author)
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He, MA (author)
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Hsu, FC (author)
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Jackson, AU (author)
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Zhao, JH (author)
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Kraja, AT (author)
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Kuhnel, B (author)
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- Laguzzi, F (author)
- Karolinska Institutet
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- Lyytikainen, LP (author)
- Karolinska Institutet
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Nolte, IM (author)
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Rauramaa, R (author)
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Riaz, M (author)
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Robino, A (author)
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Rueedi, R (author)
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Stringham, HM (author)
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Takeuchi, F (author)
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van der Most, PJ (author)
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- V. Varga, Tibor (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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Verweij, N (author)
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Ware, EB (author)
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Wen, WQ (author)
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Li, XY (author)
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Yanek, LR (author)
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Amin, N (author)
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Arnett, DK (author)
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Boerwinkle, E (author)
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Brumat, M (author)
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Cade, B (author)
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Canouil, M (author)
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Chen, YDI (author)
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Concas, MP (author)
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Connell, J (author)
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de Mutsert, R (author)
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de Silva, HJ (author)
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de Vries, PS (author)
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Demirkan, A (author)
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Ding, JZ (author)
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Eaton, CB (author)
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Faul, JD (author)
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Friedlander, Y (author)
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Gabriel, KP (author)
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Ghanbari, M (author)
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Giulianini, F (author)
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Gu, CC (author)
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Gu, DF (author)
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Harris, TB (author)
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He, J (author)
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Heikkinen, S (author)
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Heng, CK (author)
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Hunt, SC (author)
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Ikram, MA (author)
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Jonas, JB (author)
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- Wennberg, Patrik, 1972- (author)
- Umeå universitet,Allmänmedicin
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Komulainen, P (author)
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Krieger, JE (author)
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Kritchevsky, SB (author)
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Kutalik, Z (author)
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Kuusisto, J (author)
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Langefeld, CD (author)
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Langenberg, C (author)
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Launer, LJ (author)
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- Leander, K (author)
- Karolinska Institutet
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Lemaitre, RN (author)
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Lewis, CE (author)
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Liang, JJ (author)
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Alizadeh, BZ (author)
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Boezen, HM (author)
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- Franke, L (author)
- Icahn School of Medicine at Mount Sinai
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Navis, G (author)
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Rots, M (author)
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Swertz, M (author)
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Wolffenbuttel, BHR (author)
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Wijmenga, C (author)
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Liu, JJ (author)
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Magi, R (author)
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Manichaikul, A (author)
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Meitinger, T (author)
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Metspalu, A (author)
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Milaneschi, Y (author)
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Mohlke, KL (author)
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Mosley, TH (author)
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Murray, AD (author)
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Nalls, MA (author)
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Nang, EEK (author)
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Nelson, CP (author)
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Nona, S (author)
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Norris, JM (author)
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Nwuba, CV (author)
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O'Connell, J (author)
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Palmer, ND (author)
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Papanicolau, GJ (author)
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Pazoki, R (author)
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- Pedersen, NL (author)
- Karolinska Institutet
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Peters, A (author)
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- Poveda, Alaitz (author)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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Polasek, O (author)
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Porteous, DJ (author)
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Poveda, A (author)
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Raitakari, OT (author)
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Rich, SS (author)
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Risch, N (author)
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Robinson, JG (author)
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Rose, LM (author)
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Rudan, I (author)
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Schreiner, PJ (author)
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Scott, RA (author)
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Sidney, SS (author)
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Sims, M (author)
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Smith, JA (author)
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Snieder, H (author)
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Sofer, T (author)
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Starr, JM (author)
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Sternfeld, B (author)
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Strauch, K (author)
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Tang, H (author)
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Taylor, KD (author)
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Tsai, MY (author)
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Tuomilehto, J (author)
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Uitterlinden, AG (author)
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van der Ende, MY (author)
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van Heemst, D (author)
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Voortman, T (author)
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Waldenberger, M (author)
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- Franks, Paul W. (author)
- Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, USA; OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
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Wilson, G (author)
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Xiang, YB (author)
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Yao, J (author)
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Yu, CZ (author)
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Yuan, JM (author)
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Zhao, W (author)
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Zonderman, AB (author)
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Becker, DM (author)
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Boehnke, M (author)
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Bowden, DW (author)
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- de Faire, U (author)
- Karolinska Institutet
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Deary, IJ (author)
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Elliott, P (author)
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Esko, T (author)
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Freedman, BI (author)
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Froguel, P (author)
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Gasparini, P (author)
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Gieger, C (author)
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Kato, N (author)
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Laakso, M (author)
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Lakka, TA (author)
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Lehtimaki, T (author)
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- Magnusson, PKE (author)
- Karolinska Institutet
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Oldehinkel, AJ (author)
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Penninx, BWJH (author)
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Samani, NJ (author)
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Shu, XO (author)
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van der Harst, P (author)
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Van Vliet-Ostaptchouk, JV (author)
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Vollenweider, P (author)
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Wagenknecht, LE (author)
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Wang, YX (author)
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Wareham, NJ (author)
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Weir, DR (author)
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Wu, TC (author)
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Zheng, W (author)
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Zhu, XF (author)
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Evans, MK (author)
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Franks, PW (author)
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Gudnason, V (author)
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Hayward, C (author)
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Horta, BL (author)
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Kelly, TN (author)
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Liu, YM (author)
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North, KE (author)
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Pereira, AC (author)
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Ridker, PM (author)
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Tai, ES (author)
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van Dam, RM (author)
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Fox, ER (author)
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Kardia, SLR (author)
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Liu, CT (author)
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Mook-Kanamori, DO (author)
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Province, MA (author)
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Redline, S (author)
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van Duijn, CM (author)
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Rotter, JI (author)
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Kooperberg, CB (author)
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Gauderman, WJ (author)
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Psaty, BM (author)
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Rice, K (author)
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Munroe, PB (author)
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Fornage, M (author)
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Cupples, LA (author)
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Rotimi, CN (author)
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Morrison, AC (author)
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Rao, DC (author)
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Loos, RJF (author)
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(creator_code:org_t)
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et al
- 2019-01-22
- 2019
- English.
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In: Nature communications. - London : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 376-
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Kilpelainen, TO
-
Bentley, AR
-
Noordam, R
-
Sung, YJ
-
Schwander, K
-
Winkler, TW
-
show more...
-
Jakupovic, H
-
Chasman, DI
-
Manning, A
-
Ntalla, I
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Aschard, H
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Brown, MR
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de las Fuentes, ...
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Franceschini, N
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Guo, XQ
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Vojinovic, D
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Aslibekyan, S
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Feitosa, MF
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Kho, M
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Musani, SK
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Richard, M
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Wang, HM
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Wang, Z
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Bartz, TM
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Bielak, LF
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Campbell, A
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Dorajoo, R
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Fisher, V
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Franks, Paul
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Horimoto, ARVR
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Li, CW
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Lohman, KK
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Marten, J
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Sim, XL
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Smith, AV
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Tajuddin, SM
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Alver, M
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Amini, M
-
Boissel, M
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Chai, JF
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Chen, X
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Divers, J
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Evangelou, E
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Gao, C
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Graff, M
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Harris, SE
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He, MA
-
Hsu, FC
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Jackson, AU
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Zhao, JH
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Kraja, AT
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Kuhnel, B
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Laguzzi, F
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Lyytikainen, LP
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Nolte, IM
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Rauramaa, R
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Riaz, M
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Robino, A
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Rueedi, R
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Stringham, HM
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Takeuchi, F
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van der Most, PJ
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V. Varga, Tibor
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Verweij, N
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Ware, EB
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Wen, WQ
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Li, XY
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Yanek, LR
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Amin, N
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Arnett, DK
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Boerwinkle, E
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Brumat, M
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Cade, B
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Canouil, M
-
Chen, YDI
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Concas, MP
-
Connell, J
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de Mutsert, R
-
de Silva, HJ
-
de Vries, PS
-
Demirkan, A
-
Ding, JZ
-
Eaton, CB
-
Faul, JD
-
Friedlander, Y
-
Gabriel, KP
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Ghanbari, M
-
Giulianini, F
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Gu, CC
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Gu, DF
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Harris, TB
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He, J
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Heikkinen, S
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Heng, CK
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Hunt, SC
-
Ikram, MA
-
Jonas, JB
-
Wennberg, Patrik ...
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Komulainen, P
-
Krieger, JE
-
Kritchevsky, SB
-
Kutalik, Z
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Kuusisto, J
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Langefeld, CD
-
Langenberg, C
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Launer, LJ
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Leander, K
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Lemaitre, RN
-
Lewis, CE
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Liang, JJ
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Alizadeh, BZ
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Boezen, HM
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Franke, L
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Navis, G
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Rots, M
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Swertz, M
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Wolffenbuttel, B ...
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Wijmenga, C
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Liu, JJ
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Magi, R
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Manichaikul, A
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Meitinger, T
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Metspalu, A
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Milaneschi, Y
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Mohlke, KL
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Mosley, TH
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Murray, AD
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Nalls, MA
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Nang, EEK
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Nelson, CP
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Nona, S
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Norris, JM
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Nwuba, CV
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O'Connell, J
-
Palmer, ND
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Papanicolau, GJ
-
Pazoki, R
-
Pedersen, NL
-
Peters, A
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Poveda, Alaitz
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Polasek, O
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Porteous, DJ
-
Poveda, A
-
Raitakari, OT
-
Rich, SS
-
Risch, N
-
Robinson, JG
-
Rose, LM
-
Rudan, I
-
Schreiner, PJ
-
Scott, RA
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Sidney, SS
-
Sims, M
-
Smith, JA
-
Snieder, H
-
Sofer, T
-
Starr, JM
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Sternfeld, B
-
Strauch, K
-
Tang, H
-
Taylor, KD
-
Tsai, MY
-
Tuomilehto, J
-
Uitterlinden, AG
-
van der Ende, MY
-
van Heemst, D
-
Voortman, T
-
Waldenberger, M
-
Franks, Paul W.
-
Wilson, G
-
Xiang, YB
-
Yao, J
-
Yu, CZ
-
Yuan, JM
-
Zhao, W
-
Zonderman, AB
-
Becker, DM
-
Boehnke, M
-
Bowden, DW
-
de Faire, U
-
Deary, IJ
-
Elliott, P
-
Esko, T
-
Freedman, BI
-
Froguel, P
-
Gasparini, P
-
Gieger, C
-
Kato, N
-
Laakso, M
-
Lakka, TA
-
Lehtimaki, T
-
Magnusson, PKE
-
Oldehinkel, AJ
-
Penninx, BWJH
-
Samani, NJ
-
Shu, XO
-
van der Harst, P
-
Van Vliet-Ostapt ...
-
Vollenweider, P
-
Wagenknecht, LE
-
Wang, YX
-
Wareham, NJ
-
Weir, DR
-
Wu, TC
-
Zheng, W
-
Zhu, XF
-
Evans, MK
-
Franks, PW
-
Gudnason, V
-
Hayward, C
-
Horta, BL
-
Kelly, TN
-
Liu, YM
-
North, KE
-
Pereira, AC
-
Ridker, PM
-
Tai, ES
-
van Dam, RM
-
Fox, ER
-
Kardia, SLR
-
Liu, CT
-
Mook-Kanamori, D ...
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Province, MA
-
Redline, S
-
van Duijn, CM
-
Rotter, JI
-
Kooperberg, CB
-
Gauderman, WJ
-
Psaty, BM
-
Rice, K
-
Munroe, PB
-
Fornage, M
-
Cupples, LA
-
Rotimi, CN
-
Morrison, AC
-
Rao, DC
-
Loos, RJF
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Nature communica ...
- By the university
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Karolinska Institutet
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Umeå University
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Lund University