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The best COVID-19 p...
The best COVID-19 predictor is recent smell loss: a cross-sectional study
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Gerkin, RC (author)
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Ohla, K (author)
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Veldhuizen, MG (author)
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show more...
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Joseph, PV (author)
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Kelly, CE (author)
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Bakke, AJ (author)
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Steele, KE (author)
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Farruggia, MC (author)
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Pellegrino, R (author)
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Pepino, MY (author)
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Bouysset, C (author)
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Soler, GM (author)
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Pereda-Loth, V (author)
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Dibattista, M (author)
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Cooper, KW (author)
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Croijmans, I (author)
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Di Pizio, A (author)
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Ozdener, MH (author)
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Fjaeldstad, AW (author)
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Lin, C (author)
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Sandell, MA (author)
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Singh, PB (author)
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Brindha, VE (author)
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Olsson, SB (author)
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Saraiva, LR (author)
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Ahuja, G (author)
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Alwashahi, MK (author)
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Bhutani, S (author)
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D'Errico, A (author)
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Fornazieri, MA (author)
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Golebiowski, J (author)
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Hwang, LD (author)
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Öztürk, L (author)
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Roura, E (author)
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Spinelli, S (author)
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Whitcroft, KL (author)
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Faraji, F (author)
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Fischmeister, FPS (author)
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Heinbockel, T (author)
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Hsieh, JW (author)
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Huart, C (author)
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Konstantinidis, I (author)
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Menini, A (author)
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Morini, G (author)
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Olofsson, JK (author)
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Philpott, CM (author)
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Pierron, D (author)
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Shields, VDC (author)
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Voznessenskaya, VV (author)
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Albayay, J (author)
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Altundag, A (author)
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Bensafi, M (author)
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Bock, MA (author)
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Calcinoni, O (author)
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Fredborg, W (author)
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Laudamiel, C (author)
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Lim, J (author)
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- Lundström, JN (author)
- Karolinska Institutet
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Macchi, A (author)
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Meyer, P (author)
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Moein, ST (author)
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Santamaría, E (author)
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Sengupta, D (author)
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Domínguez, PP (author)
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Yanık, H (author)
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Boesveldt, S (author)
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de Groot, JHB (author)
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Dinnella, C (author)
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Freiherr, J (author)
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Laktionova, T (author)
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Mariño, S (author)
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Monteleone, E (author)
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Nunez-Parra, A (author)
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Abdulrahman, O (author)
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Ritchie, M (author)
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Thomas-Danguin, T (author)
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Walsh-Messinger, J (author)
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Al Abri, R (author)
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Alizadeh, R (author)
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Bignon, E (author)
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Cantone, E (author)
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Cecchini, MP (author)
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Chen, J (author)
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Guàrdia, MD (author)
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Hoover, KC (author)
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Karni, N (author)
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Navarro, M (author)
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Nolden, AA (author)
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Mazal, PP (author)
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Rowan, NR (author)
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Sarabi-Jamab, A (author)
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Archer, NS (author)
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Chen, B (author)
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Di Valerio, EA (author)
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Feeney, EL (author)
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Frasnelli, J (author)
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Hannum, M (author)
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Hopkins, C (author)
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Klein, H (author)
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Mignot, C (author)
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Mucignat, C (author)
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Ning, Y (author)
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Ozturk, EE (author)
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Peng, M (author)
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Saatci, O (author)
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Sell, EA (author)
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Yan, CH (author)
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Alfaro, R (author)
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Cecchetto, C (author)
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Coureaud, G (author)
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Herriman, RD (author)
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Justice, JM (author)
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Kaushik, PK (author)
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Koyama, S (author)
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Overdevest, JB (author)
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Pirastu, N (author)
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Ramirez, VA (author)
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Roberts, SC (author)
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Smith, BC (author)
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Cao, H (author)
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Wang, H (author)
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Balungwe, P (author)
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Baguma, M (author)
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Hummel, T (author)
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Hayes, JE (author)
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Reed, DR (author)
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Niv, MY (author)
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Munger, SD (author)
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Parma, V (author)
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2020
- 2020
- English.
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
- Related links:
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https://www.medrxiv....
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- BackgroundCOVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19.MethodsThis preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery.ResultsBoth C19+ and C19-groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ∼50% of participants and was best predicted by time since illness onset.ConclusionsAs smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4<OR<10), which can be deployed when viral lab tests are impractical or unavailable.
Publication and Content Type
- vet (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Gerkin, RC
-
Ohla, K
-
Veldhuizen, MG
-
Joseph, PV
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Kelly, CE
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Bakke, AJ
-
show more...
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Steele, KE
-
Farruggia, MC
-
Pellegrino, R
-
Pepino, MY
-
Bouysset, C
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Soler, GM
-
Pereda-Loth, V
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Dibattista, M
-
Cooper, KW
-
Croijmans, I
-
Di Pizio, A
-
Ozdener, MH
-
Fjaeldstad, AW
-
Lin, C
-
Sandell, MA
-
Singh, PB
-
Brindha, VE
-
Olsson, SB
-
Saraiva, LR
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Ahuja, G
-
Alwashahi, MK
-
Bhutani, S
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D'Errico, A
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Fornazieri, MA
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Golebiowski, J
-
Hwang, LD
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Öztürk, L
-
Roura, E
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Spinelli, S
-
Whitcroft, KL
-
Faraji, F
-
Fischmeister, FP ...
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Heinbockel, T
-
Hsieh, JW
-
Huart, C
-
Konstantinidis, ...
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Menini, A
-
Morini, G
-
Olofsson, JK
-
Philpott, CM
-
Pierron, D
-
Shields, VDC
-
Voznessenskaya, ...
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Albayay, J
-
Altundag, A
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Bensafi, M
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Bock, MA
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Calcinoni, O
-
Fredborg, W
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Laudamiel, C
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Lim, J
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Lundström, JN
-
Macchi, A
-
Meyer, P
-
Moein, ST
-
Santamaría, E
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Sengupta, D
-
Domínguez, PP
-
Yanık, H
-
Boesveldt, S
-
de Groot, JHB
-
Dinnella, C
-
Freiherr, J
-
Laktionova, T
-
Mariño, S
-
Monteleone, E
-
Nunez-Parra, A
-
Abdulrahman, O
-
Ritchie, M
-
Thomas-Danguin, ...
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Walsh-Messinger, ...
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Al Abri, R
-
Alizadeh, R
-
Bignon, E
-
Cantone, E
-
Cecchini, MP
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Chen, J
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Guàrdia, MD
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Hoover, KC
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Karni, N
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Navarro, M
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Nolden, AA
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Mazal, PP
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Rowan, NR
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Sarabi-Jamab, A
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Archer, NS
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Chen, B
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Di Valerio, EA
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Feeney, EL
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Frasnelli, J
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Hannum, M
-
Hopkins, C
-
Klein, H
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Mignot, C
-
Mucignat, C
-
Ning, Y
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Ozturk, EE
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Peng, M
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Saatci, O
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Sell, EA
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Yan, CH
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Alfaro, R
-
Cecchetto, C
-
Coureaud, G
-
Herriman, RD
-
Justice, JM
-
Kaushik, PK
-
Koyama, S
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Overdevest, JB
-
Pirastu, N
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Ramirez, VA
-
Roberts, SC
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Smith, BC
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Cao, H
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Wang, H
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Balungwe, P
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Baguma, M
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Hummel, T
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Hayes, JE
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Reed, DR
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Niv, MY
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Munger, SD
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Parma, V
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show less...
- Articles in the publication
- medRxiv : the pr ...
- By the university
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Karolinska Institutet