Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Search: onr:"swepub:oai:DiVA.org:oru-3516" > Dose-dependent effe...

1 of 1
Previous record
Next record
To hitlist

Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency

Albertsson-Wikland, Kerstin, 1947 (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

Aronson, A. Stefan (author)

Gustafsson, Jan (author): Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/ Gustafsson

Hagenäs, Lars (author): Karolinska Institutet

Ivarsson, Sten A. (author)

Jonsson, Björn (author): Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/ Gustafsson

Kriström, Berit (author): Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Pediatrik

Marcus, Claude (author): Karolinska Institutet

Nilsson, Karl-Olof (author): Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups

Ritzén, E. Martin (author): Karolinska Institutet

Tuvemo, Torsten (author): Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/ Gustafsson

Westphal, Otto, 1935 (author): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences

Åman, Jan (author): Örebro universitet,Hälsoakademin

show less...

(creator_code:org_t)

The Endocrine Society, 2008
2008
English.
In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 93:11, s. 4342-4350

Related links:: https://doi.org/10.1...; show more...; https://academic.oup...; http://www.ncbi.nlm.... (free); http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://gup.ub.gu.se...; https://lup.lub.lu.s...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

CONTEXT: The effect of GH therapy in short non-GH-deficient children, especially those with idiopathic short stature (ISS), has not been clearly established owing to the lack of controlled trials continuing until final height (FH).OBJECTIVE: The aim of the study was to investigate the effect on growth to FH of two GH doses given to short children, mainly with ISS, compared with untreated controls.DESIGN AND SETTING: A randomized, controlled, long-term multicenter trial was conducted in Sweden.INTERVENTION: Two doses of GH (Genotropin) were administered, 33 or 67 microg/kg.d; control subjects were untreated.SUBJECTS: A total of 177 subjects with short stature were enrolled. Of these, 151 were included in the intent to treat (AllITT) population, and 108 in the per protocol (AllPP) population. Analysis of ISS subjects included 126 children in the ITT (ISSITT) population and 68 subjects in the PP (ISSPP) population.MAIN OUTCOME MEASURES: We measured FH sd score (SDS), difference in SDS to midparenteral height (diff MPHSDS), and gain in heightSDS.RESULTS: After 5.9+/-1.1 yr on GH therapy, the FHSDS in the AllPP population treated with GH vs. controls was -1.5+/-0.81 (33 microg/kg.d, -1.7+/-0.70; and 67 microg/kg.d, -1.4+/-0.86; P<0.032), vs. -2.4+/-0.85 (P<0.001); the diff MPHSDS was -0.2+/-1.0 vs. -1.0+/-0.74 (P<0.001); and the gain in heightSDS was 1.3+/-0.78 vs. 0.2+/-0.69 (P<0.001). GH therapy was safe and had no impact on time to onset of puberty. A dose-response relationship identified after 1 yr remained to FH for all growth outcome variables in all four populations.CONCLUSION: GH treatment significantly increased FH in ISS children in a dose-dependent manner, with a mean gain of 1.3 SDS (8 cm) and a broad range of response from no gain to 3 SDS compared to a mean gain of 0.2 SDS in the untreated controls.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)

Keyword

MEDICINE
MEDICIN
Internal medicine
Invärtesmedicin
Endocrinology
Endokrinologi
Invärtesmedicin
Internal Medicine

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Journal of Clinical Endocrinology and Metabolism (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Albertsson-Wikla ...; Aronson, A. Stef ...; Gustafsson, Jan; Hagenäs, Lars; Ivarsson, Sten A ...; Jonsson, Björn; show more...; Kriström, Berit; Marcus, Claude; Nilsson, Karl-Ol ...; Ritzén, E. Marti ...; Tuvemo, Torsten; Westphal, Otto, ...; Åman, Jan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

Articles in the publication: Journal of Clini ...

By the university: Örebro University; University of Gothenburg; Lund University; Umeå University; Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se