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The heritable basis...
The heritable basis of gene-environment interactions in cardiometabolic traits
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Poveda, Alaitz (författare)
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Chen, Yan (författare)
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Brändström, Anders (författare)
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Engberg, Elisabeth (författare)
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Hallmans, Göran (författare)
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Johansson, Ingegerd (författare)
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Renström, Frida (författare)
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Kurbasic, Azra (författare)
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Franks, Paul W. (författare)
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- SPRINGER 2017
- 2017
- Engelska.
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Ingår i: Diabetologia. - 0012-186X. ; 60:3, 442-452
Abstract
Ämnesord
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- Aims/hypothesis Little is known about the heritable basis of gene-environment interactions in humans. We therefore screened multiple cardiometabolic traits to assess the probability that they are influenced by genotype-environment interactions. Methods Fourteen established environmental risk exposures and 11 cardiometabolic traits were analysed in the VIKING study, a cohort of 16,430 Swedish adults from 1682 extended pedigrees with available detailed genealogical, phenotypic and demographic information, using a maximum likelihood variance decomposition method in Sequential Oligogenic Linkage Analysis Routines software. Results All cardiometabolic traits had statistically significant heritability estimates, with narrow-sense heritabilities (h (2)) ranging from 24% to 47%. Genotype-environment interactions were detected for age and sex (for the majority of traits), physical activity (for triacylglycerols, 2 h glucose and diastolic BP), smoking (for weight), alcohol intake (for weight, BMI and 2 h glucose) and diet pattern (for weight, BMI, glycaemic traits and systolic BP). Genotype-age interactions for weight and systolic BP, genotype-sex interactions for BMI and triacylglycerols and genotype-alcohol intake interactions for weight remained significant after multiple test correction. Conclusion/hypothesis Age, sex and alcohol intake are likely to be major modifiers of genetic effects for a range of cardiometabolic traits. This information may prove valuable for studies that seek to identify specific loci that modify the effects of lifestyle in cardiometabolic disease.
Ämnesord
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Public Health, Global Health, Social Medicine and Epidemiology (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv)
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Medical Genetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Medicinsk genetik (hsv)
Nyckelord
- Cardiometabolic traits
- Environment
- Extended pedigrees
- Gene
- Heritability
- Interaction
- VIKINGstudy
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