Sökning: onr:"22096846" > The interface of pr...
Fältnamn | Indikatorer | Metadata |
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000 | 05092naa a22010453a 4500 | |
001 | 22096846 | |
003 | SE-LIBR | |
005 | 20171209153203.0 | |
007 | cr|||||||||||| | |
008 | 171209s2012 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-797952 uri |
024 | 7 | a urn:nbn:se:su:diva-797952 urn |
024 | 7 | a 10.1002/pro.20712 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Liberles, David A.4 aut |
245 | 1 0 | a The interface of protein structure, protein biophysics, and molecular evolutionh [Elektronisk resurs] |
260 | c 2012 | |
500 | a <p>AuthorCount:33;</p> | |
500 | a Published | |
506 | 0 | a gratis |
520 | a The interface of protein structural biology, protein biophysics, molecular evolution, and molecular population genetics forms the foundations for a mechanistic understanding of many aspects of protein biochemistry. Current efforts in interdisciplinary protein modeling are in their infancy and the state-of-the art of such models is described. Beyond the relationship between amino acid substitution and static protein structure, protein function, and corresponding organismal fitness, other considerations are also discussed. More complex mutational processes such as insertion and deletion and domain rearrangements and even circular permutations should be evaluated. The role of intrinsically disordered proteins is still controversial, but may be increasingly important to consider. Protein geometry and protein dynamics as a deviation from static considerations of protein structure are also important. Protein expression level is known to be a major determinant of evolutionary rate and several considerations including selection at the mRNA level and the role of interaction specificity are discussed. Lastly, the relationship between modeling and needed high-throughput experimental data as well as experimental examination of protein evolution using ancestral sequence resurrection and in vitro biochemistry are presented, towards an aim of ultimately generating better models for biological inference and prediction. | |
650 | 7 | a Natural Sciences2 hsv |
650 | 7 | a Biological Sciences2 hsv |
650 | 7 | a Biochemistry and Molecular Biology2 hsv |
650 | 7 | a Naturvetenskap2 hsv0 264446 |
650 | 7 | a Biologiska vetenskaper2 hsv |
650 | 7 | a Biokemi och molekylärbiologi2 hsv |
653 | 0 | a evolutionary modeling |
653 | 0 | a domain evolution |
653 | 0 | a sequence-structure-function relationships |
653 | 0 | a protein dynamics |
653 | 0 | a protein thermodynamics |
653 | 0 | a gene duplication |
653 | 0 | a protein expression |
653 | 0 | a ancestral sequence reconstruction |
700 | 1 | a Teichmann, Sarah A.4 aut |
700 | 1 | a Bahar, Ivet4 aut |
700 | 1 | a Bastolla, Ugo4 aut |
700 | 1 | a Bloom, Jesse4 aut |
700 | 1 | a Bornberg-Bauer, Erich4 aut |
700 | 1 | a Colwell, Lucy J.4 aut |
700 | 1 | a de Koning, A. P. Jason4 aut |
700 | 1 | a Dokholyan, Nikolay V.4 aut |
700 | 1 | a Echave, Julian4 aut |
700 | 1 | a Elofsson, Arne4 aut |
700 | 1 | a Gerloff, Dietlind L.4 aut |
700 | 1 | a Goldstein, Richard A.4 aut |
700 | 1 | a Grahnen, Johan A.4 aut |
700 | 1 | a Holder, Mark T.4 aut |
700 | 1 | a Lakner, Clemens4 aut |
700 | 1 | a Lartillot, Nicholas4 aut |
700 | 1 | a Lovell, Simon C.4 aut |
700 | 1 | a Naylor, Gavin4 aut |
700 | 1 | a Perica, Tina4 aut |
700 | 1 | a Pollock, David D.4 aut |
700 | 1 | a Pupko, Tal4 aut |
700 | 1 | a Regan, Lynne4 aut |
700 | 1 | a Roger, Andrew4 aut |
700 | 1 | a Rubinstein, Nimrod4 aut |
700 | 1 | a Shakhnovich, Eugene4 aut |
700 | 1 | a Sjoelander, Kimmen4 aut |
700 | 1 | a Sunyaev, Shamil4 aut |
700 | 1 | a Teufel, Ashley I.4 aut |
700 | 1 | a Thorne, Jeffrey L.4 aut |
700 | 1 | a Thornton, Joseph W.4 aut |
700 | 1 | a Weinreich, Daniel M.4 aut |
700 | 1 | a Whelan, Simon4 aut |
710 | 1 2 | a Stockholms universitetb Naturvetenskapliga fakulteten4 pbl |
772 | 1 8 | i channel recordw 19642870 |
773 | 0 8 | i Värdpublikationt Protein Scienceg 21:6, 769-785x 0961-8368 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795 |
856 | 4 0 | u http://dx.doi.org/10.1002/pro.2071 |
856 | 4 0 | u http://su.diva-portal.org/smash/get/diva2:551573/FULLTEXT02 |
950 | k | 6 650a Atomerw hu Naturvetenskap |
950 | k | 6 650a Experimentw hu Naturvetenskap |
950 | k | 6 650a Fysikw hu Naturvetenskap |
950 | k | 6 650a Kemiw hu Naturvetenskap |
950 | k | 6 650a Kloningw hu Naturvetenskap |
950 | k | 6 650a Laboratorierw hu Naturvetenskap |
950 | k | 6 650a Marinbiologiw hu Naturvetenskap |
950 | k | 6 650a Matematikw hu Naturvetenskap |
950 | k | 6 650a Medicinska experimentw hu Naturvetenskap |
950 | k | 6 650a Tyngdlagenw hu Naturvetenskap |
950 | k | 6 650a Utvecklingsläraw hu Naturvetenskap |
841 | 5 APISa x ab 171210||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:su:diva-797952 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-79795 |
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