Oxygen therapy in ST-elevation myocardial infarction.

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Oxygen therapy in ST-elevation myocardial infarction.

Hofmann, Robin (författare): Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden,Stockholm South General Hospital,Division of Cardiology, Department of Clinical Science and Education, Karolinska Institutet

Witt, Nils (författare): Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden,Stockholm South General Hospital,Division of Cardiology, Department of Clinical Science and Education, Karolinska Institutet

Lagerqvist, Bo, 1952- (författare): Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden,Uppsala University Hospital,Cardiology, Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset

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Jernberg, Tomas (författare): Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden,Danderyd Hospital,Cardiology, Department of Clinical Sciences, Karolinska Institutet

Lindahl, Bertil, 1957- (författare): Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Sweden; Uppsala Univ, Sweden,Uppsala University Hospital,Cardiology, Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset

Erlinge, David (författare): Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Department of Cardiology, Clinical Sciences, Lund University

Herlitz, Johan, 1949- (författare): University of Borås,Högskolan i Borås,Akademin för vård, arbetsliv och välfärd,Department of Cardiology, Sahlgrenska University Hospital,Univ Boras, Dept Hlth Sci, S-50190 Boras, Sweden;Sahlgrens Univ Hosp, Dept Cardiol, S-41345 Gothenburg, Sweden

Alfredsson, Joakim (författare): Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping University Hospital,Department of Medical and Health Sciences, Linköping University

Linder, Rikard (författare): Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden,Danderyd Hospital,Cardiology, Department of Clinical Sciences, Karolinska Institutet

Omerovic, Elmir (författare): Department of Cardiology, Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Cardiol, S-41345 Gothenburg, Sweden

Angerås, Oskar (författare): Department of Cardiology, Sahlgrenska University Hospital,Sahlgrens Univ Hosp, Dept Cardiol, S-41345 Gothenburg, Sweden

Venetsanos, Dimitrios (författare): Linköping University,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping University Hospital,Department of Medical and Health Sciences, Linköping University

Kellerth, Thomas (författare): Department of Cardiology, Örebro University Hospital,Orebro Univ Hosp, Dept Cardiol, S-70185 Orebro, Sweden

Sparv, David (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Cardiology, Clinical Sciences, Lund University

Lauermann, Jörg (författare): Division of Cardiology, Department of Internal Medicine, Ryhov Hospital,Ryhov Hosp, Dept Internal Med, Div Cardiol, Sjukhusgatan, S-55305 Jonkoping, Sweden,Ryhov County Hospital, Jönköping

Barmano, Neshro (författare): Division of Cardiology, Department of Internal Medicine, Ryhov Hospital,Ryhov Hosp, Dept Internal Med, Div Cardiol, Sjukhusgatan, S-55305 Jonkoping, Sweden,Ryhov County Hospital, Jönköping

Verouhis, Dinos (författare): Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital

Östlund, Ollie (författare): Uppsala University,Uppsala Clinical Research Center, Uppsala University

Svensson, Leif (författare): Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden,Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital

James, Stefan K, 1964- (författare): Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden,Uppsala University Hospital,Cardiology, Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset

Östlund, Olof Petter (författare): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

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2018-06-14
2018
Engelska.
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 39:29, s. 2730-2739

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Aims: To determine whether supplemental oxygen in patients with ST-elevation myocardial infarction (STEMI) impacts on procedure-related and clinical outcomes.Methods and results: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) trial randomized patients with suspected myocardial infarction (MI) to receive oxygen at 6 L/min for 6-12 h or ambient air. In this pre-specified analysis, we included only STEMI patients who underwent percutaneous coronary intervention (PCI). In total, 2807 patients were included, 1361 assigned to receive oxygen, and 1446 assigned to ambient air. The pre-specified primary composite endpoint of all-cause death, rehospitalization with MI, cardiogenic shock, or stent thrombosis at 1 year occurred in 6.3% (86 of 1361) of patients allocated to oxygen compared to 7.5% (108 of 1446) allocated to ambient air [hazard ratio (HR) 0.85, 95% confidence interval (95% CI) 0.64-1.13; P = 0.27]. There was no difference in the rate of death from any cause (HR 0.86, 95% CI 0.61-1.22; P = 0.41), rate of rehospitalization for MI (HR 0.92, 95% CI 0.57-1.48; P = 0.73), rehospitalization for cardiogenic shock (HR 1.05, 95% CI 0.21-5.22; P = 0.95), or stent thrombosis (HR 1.27, 95% CI 0.46-3.51; P = 0.64). The primary composite endpoint was consistent across all subgroups, as well as at different time points, such as during hospital stay, at 30 days and the total duration of follow-up up to 1356 days.Conclusions: Routine use of supplemental oxygen in normoxemic patients with STEMI undergoing primary PCI did not significantly affect 1-year all-cause death, rehospitalization with MI, cardiogenic shock, or stent thrombosis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Oxygen
Percutaneous coronary intervention
Reactive oxygen species
Registry-based randomized clinical trial
Reperfusion injury
ST-elevation myocardial infarction
Människan i vården
Människan i vården
Oxygen
Percutaneous coronary intervention
Reactive oxygen species
Registry-based randomized clinical trial
Reperfusion injury
ST-elevation myocardial infarction

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: European Heart J ...

Av lärosätet: Högskolan i Borås; Uppsala universitet; Karolinska Institutet; Linköpings universitet; Lunds universitet

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