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Sökning: WFRF:(Pajalic Zada) > Leon Larios Fatima > Maternal plasma lev...

  • Uvnäs-Moberg, KerstinSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjurens miljö och hälsa (HMH),Department of Animal Environment and Health,University of Agriculture (SLU), Uppsala (SWE),University of Agriculture (SLU), Uppsala, Sweden (författare)

Maternal plasma levels of oxytocin during physiological childbirth : a systematic review with implications for uterine contractions and central actions of oxytocin

  • Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

  • 2019-08-09
  • Springer Science and Business Media LLC,2019
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:hv-14349
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-14349URI
  • https://doi.org/10.1186/s12884-019-2365-9DOI
  • https://res.slu.se/id/publ/101384URI
  • https://gup.ub.gu.se/publication/283669URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17578URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funders: EU COST IS1405 birth
  • BACKGROUND: Oxytocin is a key hormone in childbirth, and synthetic oxytocin is widely administered to induce or speed labour. Due to lack of synthetized knowledge, we conducted a systematic review of maternal plasma levels of oxytocin during physiological childbirth, and in response to infusions of synthetic oxytocin, if reported in the included studies.METHODS: An a priori protocol was designed and a systematic search was conducted in PubMed, CINAHL, and PsycINFO in October 2015. Search hits were screened on title and abstract after duplicates were removed (n = 4039), 69 articles were examined in full-text and 20 papers met inclusion criteria. As the articles differed in design and methodology used for analysis of oxytocin levels, a narrative synthesis was created and the material was categorised according to effects.RESULTS: Basal levels of oxytocin increased 3-4-fold during pregnancy. Pulses of oxytocin occurred with increasing frequency, duration, and amplitude, from late pregnancy through labour, reaching a maximum of 3 pulses/10 min towards the end of labour. There was a maximal 3- to 4-fold rise in oxytocin at birth. Oxytocin pulses also occurred in the third stage of labour associated with placental expulsion. Oxytocin peaks during labour did not correlate in time with individual uterine contractions, suggesting additional mechanisms in the control of contractions. Oxytocin levels were also raised in the cerebrospinal fluid during labour, indicating that oxytocin is released into the brain, as well as into the circulation. Oxytocin released into the brain induces beneficial adaptive effects during birth and postpartum. Oxytocin levels following infusion of synthetic oxytocin up to 10 mU/min were similar to oxytocin levels in physiological labour. Oxytocin levels doubled in response to doubling of the rate of infusion of synthetic oxytocin.CONCLUSIONS: Plasma oxytocin levels increase gradually during pregnancy, and during the first and second stages of labour, with increasing size and frequency of pulses of oxytocin. A large pulse of oxytocin occurs with birth. Oxytocin in the circulation stimulates uterine contractions and oxytocin released within the brain influences maternal physiology and behaviour during birth. Oxytocin given as an infusion does not cross into the mother's brain because of the blood brain barrier and does not influence brain function in the same way as oxytocin during normal labour does.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ekström-Bergström, Anette,1958-Högskolan i Skövde,Högskolan Väst,Avdelningen för omvårdnad - avancerad nivå,University of Skövde, School of Health and Education, Skövde (SWE),LOVHH LINA,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Health Sciences, University West, Trollhättan, Sweden,Kvinna, barn, ungdom och familj (WomFam), Woman, Child, Youth and Family(Swepub:his)eksa (författare)
  • Berg, Marie,1955Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Institute of Health and Care Sciences,University of Gothenburg, Institute of Health and Care Sciences, Gothenburg (SWE),Institute of Health and Care Sciences, University of Gothenburg, Sweden / Centre for Person-Centred Care, University of Gothenburg, Sweden(Swepub:gu)xbmary (författare)
  • Buckley, SarahThe University of Queensland, School of Public Health, Brisbane (AUS),School of Public Health, University of Queensland, Brisbane, Australia (författare)
  • Pajalic, ZadaOslo and Akershus University College of Applied Sciences, Faculty of Health Sciences Oslo (NOR),Faculty of Health Sciences, Oslo and Akershus University, College of Applied Sciences, Oslo, Norway (författare)
  • Hadjigeorgiou, EleniFaculty of Health Sciences, Cyprus, University of Technology, Limassol, Cyprus (författare)
  • Kotłowska, AlicjaMedical University of Gdańsk, Faculty of Health Sciences with Subfaculty of Nursing and Institute of Maritime and Tropical Medicine, Gdańsk (POL),Faculty of Health Sciences with Subfaculty of Nursing, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk, Gdańsk, Poland (författare)
  • Lengler, LuiseMidwifery Research and Education Unit, Hannover Medical School, Hannover (DEU),Midwifery Research and Education Unit, Hannover Medical School, Hannover, Germany (författare)
  • Kielbratowska, BogumilaMedical University of Gdańsk, Faculty of Medical Sciences, Gdańsk (POL),Faculty of Medical Sciences, Medical University of Gdańsk, Gdańsk, Poland (författare)
  • Leon-Larios, FatimaUniversity of Seville, Faculty of Nursing, Physiotherapy and Podiatry, Seville (ESP),Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, Seville, Spain (författare)
  • Magistretti, Claudia MeierLucerne University of Applied Sciences and Arts, Department of Social Work Center for Health Promotion and Social Participation, Luzern (CHE),Department of Social Work Center for Health Promotion and Social Participation, Lucerne University of Applied Sciences and Arts, Luzern, Switzerland (författare)
  • Downe, SooUniversity of Central Lancashire, Research in Childbirth and Health (ReaCH) group, Preston (GBR),Research in Childbirth and Health (ReaCH) Group, University of Central Lancashire, Preston, United Kingdom (författare)
  • Lindström, BengtNorwegian University of Science and Technology, Trondheim (NOR),Norwegian University of Science and Technology, Trondheim, Norway (författare)
  • Dencker, Anna,1956Gothenburg University,Göteborgs universitet,Institutionen för vårdvetenskap och hälsa,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Health and Care Sciences,University of Gothenburg Centre for person-centred care (GPCC),University of Gothenburg, Institute of Health and Care Sciences, Gothenburg (SWE),Institute of Health and Care Sciences, University of Gothenburg, Sweden / Centre for Person-Centred Care, University of Gothenburg, Sweden(Swepub:gu)xdenan (författare)
  • Sveriges lantbruksuniversitetInstitutionen för husdjurens miljö och hälsa (HMH) (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:BMC Pregnancy and Childbirth: Springer Science and Business Media LLC19:11471-2393

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