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Sökning: WFRF:(Hamsten Anders) > (2005-2009) > Odeberg Jacob > APC resistance duri...

  • van Rooijen, Marianne (författare)

APC resistance during the normal menstrual cycle

  • Artikel/kapitelEngelska2007

Förlag, utgivningsår, omfång ...

  • 2007
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-17165
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-17165URI
  • https://doi.org/10.1160/TH07-02-0139DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:116328493URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20100525
  • Increased serum levels of endogenous as well as exogenous estrogen are regarded to be responsible for acquired activated protein C (APC) resistance. It was the objective of this study to evaluate whether the physiological increase in serum estradiol concentration during the normal menstrual cycle affects the individual's sensitivity to APC. Seventy-two women with normal menstrual cycles were included in the study. Blood samples for analysis of estradiol (E2), progesterone (P4) and APC resistance were drawn at two time points of the menstrual cycle (day 3-5 and day 22-25). Two methods of measuringAPC resistance were used: the activated partial thromboplastin time (aPTT)-based assay and the endogenous thrombin potential (ETP)-basedAPC resistance test. Independent of the method used, no changes in APC resistance were found, even though the E2 concentration increased significantly between the two menstrual phases. No correlations between E2 levels andAPC resistance, P4 levels and APC resistance or changes in E2 concentrations and changes in APC resistance were detected. Ten women were carriers of the factor V-Leiden mutation, Their baseline APC resistance was increased, but their response to elevated E2 during the menstrual cycle did not differ from that of non-carriers. In conclusion, our observations suggest that physiological differences in serum levels of estradiol and progesterone between the early follicular and the luteal phase in a normal menstrual cycle do not have any significant impact on the individual's sensitivity to APC.

Ämnesord och genrebeteckningar

  • menstrual cycle
  • APC resistance
  • ETP-based
  • aPTT-based
  • estradiol
  • activated protein-c
  • factor-v gene
  • hormone replacement therapy
  • oral-contraceptives
  • venous thrombosis
  • acquired-resistance
  • leiden mutation
  • women
  • risk
  • thromboembolism

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Silveira, AngelaKarolinska Institutet (författare)
  • Thomassen, Stella (författare)
  • Odeberg, JacobKarolinska Institutet,KTH,Genteknologi(Swepub:kth)u1e4yljo (författare)
  • Hamsten, AndersKarolinska Institutet (författare)
  • Rosing, Jan (författare)
  • Bremme, KatarinaKarolinska Institutet (författare)
  • Karolinska InstitutetGenteknologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Thrombosis and Haemostasis98:6, s. 1246-12510340-62452567-689X

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