Intracranial haemorrhage alters scalp potential distributions in bioimpedance cerebral monitoring applications: preliminary results from FEM simulation on a realistic head model and human subjects

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: L773:0094 2405 OR L773:2473 4209 > Intracranial haemor...

Atefi, Seyed RezaKTH,Medicinska sensorer, signaler och system,Harvard Univsersity (författare)

Intracranial haemorrhage alters scalp potential distributions in bioimpedance cerebral monitoring applications : preliminary results from FEM simulation on a realistic head model and human subjects

Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

2016-01-13
American Association of Physicists in Medicine,2016
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:kth-176635
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-176635URI
https://doi.org/10.1118/1.4939256DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-8614URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

QC 20170111
QS 2015
Purpose: Current diagnostic neuroimaging for detection of intracranial hemorrhage (ICH) is limited to fixed scanners requiring patient transport and extensive infrastructure support. ICH diagnosis would therefore benefit from a portable diagnostic technology, such as electrical bioimpedance (EBI). Through simulations and patient observation, the authors assessed the influence of unilateral ICH hematomas on quasisymmetric scalp potential distributions in order to establish the feasibility of EBI technology as a potential tool for early diagnosis. Methods: Finite element method (FEM) simulations and experimental leftright hemispheric scalp potential differences of healthy and damaged brains were compared with respect to the asymmetry caused by ICH lesions on quasisymmetric scalp potential distributions. In numerical simulations, this asymmetry was measured at 25 kHz and visualized on the scalp as the normalized potential difference between the healthy and ICH damaged models. Proof-of-concept simulations were extended in a pilot study of experimental scalp potential measurements recorded between 0 and 50 kHz with the authors custom-made bioimpedance spectrometer. Mean leftright scalp potential differences recorded from the frontal, central, and parietal brain regions of ten healthy control and six patients suffering from acute/subacute ICH were compared. The observed differences were measured at the 5% level of significance using the two-sample Welch ttest. Results: The 3D-anatomically accurate FEM simulations showed that the normalized scalp potential difference between the damaged and healthy brain models is zero everywhere on the head surface, except in the vicinity of the lesion, where it can vary up to 5%. The authors preliminary experimental results also confirmed that the leftright scalp potential difference in patients with ICH (e.g., 64 mV) is significantly larger than in healthy subjects (e.g., 20.8 mV; P < 0.05). Conclusions: Realistic, proof-of-concept simulations confirmed that ICH affects quasisymmetric scalp potential distributions. Pilot clinical observations with the authors custom-made bioimpedance spectrometer also showed higher leftright potential differences in the presence of ICH, similar to those of their simulations, that may help to distinguish healthy subjects from ICH patients. Although these pilot clinical observations are in agreement with the computer simulations, the small sample size of this study lacks statistical power to exclude the influence of other possible confounders such as age, ex, and electrode positioning. The agreement with previously published simulation-based and clinical results, however, suggests that EBI technology may be potentially useful for ICH detection.

Ämnesord och genrebeteckningar

TEKNIK OCH TEKNOLOGIER Medicinteknik hsv//swe
ENGINEERING AND TECHNOLOGY Medical Engineering hsv//eng
bioimpedance; FEM simulations; intracranial hemorrhage; prehospital triage; scalp equipotential lines
Applied Medical Technology
Tillämpad medicinsk teknik
Människan i vården

Biuppslag (personer, institutioner, konferenser, titlar ...)

Seoane, FernandoHögskolan i Borås,KTH,Medicinska sensorer, signaler och system,Akademin för vård, arbetsliv och välfärd,KTH-School of Technology and Health(Swepub:hb)fsm (författare)
Kamalian, Shervin (författare)
Rosenthal, Eric (författare)
Lev, MichaelMassachussets University Hospital (författare)
Bonmassar, GiorgioHarvard University (författare)
KTHMedicinska sensorer, signaler och system (creator_code:org_t)

Sammanhörande titlar

Ingår i:Medical Physics: American Association of Physicists in Medicine43:2, s. 675-6862473-42090094-2405

Internetlänk

Hitta via bibliotek

Medical Physics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Atefi, Seyed Rez ...; Seoane, Fernando; Kamalian, Shervi ...; Rosenthal, Eric; Lev, Michael; Bonmassar, Giorg ...

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik

Artiklar i publikationen: Medical Physics

Av lärosätet: Kungliga Tekniska Högskolan; Högskolan i Borås

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se