High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

Tyck till om SwePub Sök här!

Hases, LinneaKarolinska Institutet,KTH,Cellulär och klinisk proteomik,Karolinska Institute (författare)

QC 20201009
There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor beta (ERβ) can attenuate CRC development. How estrogen impacts the colon under HFD and related sex differences has, however, not been investigated. To dissect this, mice were fed control diet or HFD for 13 weeks and administered receptor-selective estrogenic ligands for the last three weeks. We recorded impact on metabolism, colon crypt proliferation, macrophage infiltration, and the colon transcriptome. We found clear sex differences in the colon transcriptome and in the impact by HFD and estrogens, including on clock genes. ERα-selective activation reduced body weight and generated systemic effects, whereas ERβ-selective activation had local effects in the colon, attenuating HFD-induced macrophage infiltration and epithelial cell proliferation. We here demonstrate how HFD and estrogens modulate the colon microenvironment in a sex- and ER-specific manner.

Archer, AmenaKarolinska Institutet,KTH,Skolan för kemi, bioteknologi och hälsa (CBH)(Swepub:kth)u131bapq (författare)
Indukuri, RajithaKarolinska Institutet,KTH,Cellulär och klinisk proteomik(Swepub:kth)u1h2gbg8 (författare)
Birgersson, MadeleineKarolinska Institutet (författare)
Savva, Christina (författare)
Korach-André, Marion (författare)
Williams, Cecilia,Professor,1969-Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u1ygqmuy (författare)
KTHCellulär och klinisk proteomik (creator_code:org_t)

Av författaren/redakt...: Hases, Linnea; Archer, Amena; Indukuri, Rajith ...; Birgersson, Made ...; Savva, Christina; Korach-André, Ma ...; visa fler...; Williams, Cecili ...; visa färre...

Om ämnet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.