Prognostic value of early sustained ventricular arrhythmias in ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: A substudy of VALIDATE-SWEDEHEART trial

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Prognostic value of early sustained ventricular arrhythmias in ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention : A substudy of VALIDATE-SWEDEHEART trial

Demidova, Marina M. (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups

Rylance, Rebecca (författare): Lund University,Lunds universitet,Karolinska Institutet,Lund Univ, Dept Cardiol Clin Sci, Lund, Sweden.,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine

Koul, Sasha (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups

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Dworeck, Christian (författare): Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.

James, Stefan, 1964- (författare): Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Institutionen för kirurgiska vetenskaper,Klinisk fysiologi,Uppsala Univ, Sweden

Aasa, Mikael (författare): Department of Cardiology, Södersjukhuset, Stockholm, Sweden,Soder Sjukhuset, Dept Cardiol, Stockholm, Sweden.,Stockholm South General Hospital

Hamid, Mehmet (författare): Department of Cardiology, Mälarsjukhuset, Eskilstuna, Sweden,Malarsjukhuset, Dept Cardiol, Eskilstuna, Sweden.,Mälar Hospital

Swahn, Eva (författare): Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US,Linköping University Hospital

Hambraeus, Kristina (författare): Department of Cardiology, Falun Hospital, Falun, Sweden,Falun Cent Hosp, Dept Cardiol, Falun, Sweden.,Falun Central Hospital

Danielewicz, Mikael (författare): PCI-Unit, Karlstad Hospital, Karlstad, Sweden,Karlstad Hosp, PCI Unit, Karlstad, Sweden.

Linder, Rikard (författare): Department of Cardiology, Danderyd Hospital, Stockholm, Sweden,Danderyd Hosp, Dept Cardiol, Stockholm, Sweden.

Fröbert, Ole, 1964- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Hlth, Dept Cardiol, Örebro, Sweden.

Grimfjärd, Per (författare): Department of Internal Medicine, Västmanlands Hospital, Västerås, Sweden,Vastmanlands Hosp, Dept Internal Med, Västerås, Sweden.

Stewart, Jason (författare): Department of Cardiology, Skaraborgs Hospital, Skövde, Sweden,Skaraborgs Hosp, Dept Cardiol, Skövde, Sweden.

Henareh, Loghman (författare): Karolinska Institutet,Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.,Karolinska University Hospital

Andersson, Jonas (författare): Umeå University,Umeå universitet,Kardiologi,Umeå Univ, Dept Cardiol, Umeå, Sweden.

Wagner, Henrik (författare): Department of Cardiology, Helsingborg Hospital, Helsingborg, Sweden,Helsingborg Hosp, Dept Cardiol, Helsingborg, Sweden.

Erlinge, David (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups

Platonov, Pyotr G. (författare): Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Electrocardiology Research Group - CIEL,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups

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Elsevier, 2023
2023
Engelska.
Ingår i: Heart rhythm O2. - : Elsevier. - 2666-5018. ; 4:3, s. 200-206

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

BACKGROUND: Prognostic assessment of ventricular tachycardia (VT) or ventricular fibrillation (VF) in ST-segment elevation myocardial infarction (STEMI) is based mainly on distinguishing between early (<48 hours) and late arrhythmias, and does not take into account its time distribution with regard to reperfusion, or type of arrhythmia.OBJECTIVE: We analyzed the prognostic value of early ventricular arrhythmias (VAs) in STEMI with regard to their type and timing.METHODS: The prespecified analysis of the multicenter prospective Bivalirudin versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarctionin Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease evaluated according to Recommended Therapies Registry Trial included 2886 STEMI patients undergoing primary percutaneous coronary intervention (PCI). VA episodes were characterized regarding their type and timing. Survival status at 180 days was assessed through the population registry.RESULTS: Nonmonomorphic VT or VF was observed in 97 (3.4%) and monomorphic VT in 16 (0.5%) patients. Only 3 (2.7%) early VA episodes occurred after 24 hours from symptom onset. VA was associated with higher risk of death (hazard ratio 3.59; 95% confidence interval [CI] 2.01-6.42) after adjustment for age, sex, and STEMI localization. VA after PCI was associated with an increased mortality compared with VA before PCI (hazard ratio 6.68; 95% CI 2.90-15.41). Early VA was associated with in-hospital mortality (odds ratio 7.39; 95% CI 3.68-14.83) but not with long-term prognosis in patients discharged alive. The type of VA was not associated with mortality.CONCLUSION: VA after PCI was associated with an increased mortality compared with VA before PCI. Long-term prognosis did not differ between patients with monomorphic VT and nonmonomorphic VT or VF, but events were few. VA incidence during 24 to 48 hours of STEMI is negligibly low, thus precluding assessment of its prognostic importance.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Monomorphic ventricular tachycardia
PCI
STEMI
Ventricular arrhythmias
Ventricular fibrillation
Monomorphic ventricular tachycardia
PCI
STEMI
Ventricular arrhythmias
Ventricular fibrillation

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Örebro universitet; Umeå universitet; Karolinska Institutet; Uppsala universitet; Linköpings universitet; Lunds universitet

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