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The Contribution of GJB2 (Connexin 26) 35delG to Age-Related Hearing Impairment and Noise-Induced Hearing Loss

Van Eyken, Els (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Fransen, Erik (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Topsakal, Vedat (författare)
Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
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Hendrickx, Jan-Jaap (författare)
Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
Demeester, Kelly (författare)
Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
Van de Heyning, Paul (författare)
Department of Otorhinolaryngology, University Hospital of Antwerp, Antwerp, Belgium
Mäki-Torkko, Elina (författare)
Örebro universitet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Öronkliniken US,Department of Otorhinolaryngology, University of Oulu, Oulu, Finland,Institutionen för medicinska vetenskaper
Hannula, Samuli (författare)
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Sorri, Martti (författare)
Department of Otorhinolaryngology, University of Oulu, Oulu, Finland
Jensen, Mona (författare)
Department of Audiology, Bispebjerg Hospital (BBH) H:S, Copenhagen, Denmark
Parving, Agnete (författare)
Department of Audiology, Bispebjerg Hospital (BBH) H:S, Copenhagen, Denmark
Bille, Mikael (författare)
Department of Audiology, Bispebjerg Hospital (BBH) H:S, Copenhagen, Denmark
Bauer, Manuela (författare)
Department of Otorhinolaryngology, University of Tüebingen, Tüebingen, Germany;
Pfister, Markus (författare)
Department of Otorhinolaryngology, University of Tüebingen, Tüebingen, Germany
Bonaconsa, Amanda (författare)
Department of Oto-surgery, University Hospital Padova, Padova, Italy
Mazzoli, Manuela (författare)
Department of Oto-surgery, University Hospital Padova, Padova, Italy
Orzan, Eva (författare)
Department of Oto-surgery, University Hospital Padova, Padova, Italy
Espeso, Angeles (författare)
Welsh hearing Institute, University Hospital of Wales, Cardiff, U.K.
Stephens, Dafydd (författare)
Welsh hearing Institute, University Hospital of Wales, Cardiff, U.K.
Verbruggen, Katia (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Huyghe, Joke (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Dhooge, Ingeborg (författare)
Department of Otorhinolaryngology, University Hospital of Gent, Gent, Belgium
Huygen, Patrick (författare)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Kremer, Hannie (författare)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Cremers, Cor (författare)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Manninen, Minna (författare)
Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Pyykkö, Ilmari (författare)
Department of Otorhinolaryngology, University of Tampere, Tampere, Finland
Rajkowska, Elzbieta (författare)
Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Lodz, Poland
Pawelczyk, Malgorzata (författare)
Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Lodz, Poland
Sliwinska-Kowalska, Mariola (författare)
Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Lodz, Poland
Steffens, Mikael (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Wienker, Thomas (författare)
Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Van Camp, Guy (författare)
University of Antwerp, Belgium,Department of Medical Genetics, University of Antwerp, the Netherlands
Van Laer, Lut (författare)
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Kunst, Sylvia (författare)
Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2007
2007
Engelska.
Ingår i: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 28:7, s. 970-975
Relaterad länk:
http://www.ncbi.nlm....
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https://journals.lww...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Hypothesis: The common GJB2 (Connexin 26) 35delG mutation might contribute to the development of age-related hearing impairment (ARHI) and noise-induced hearing loss (NIHL).Background: GJB2, a gene encoding a gap junction protein expressed in the inner ear, has been suggested to be involved in the potassium recycling pathway in the cochlea. GJB2 mutations account for a large number of individuals with nonsyndromic recessive hearing loss, with 35delG being the most frequent mutation in populations of European origin. Other genes involved in potassium homeostasis have been suggested to be associated with ARHI and NIHL, and distortion product otoacoustic emission distortions indicative of hearing loss alterations have been found in 35delG carriers.Method: We genotyped 35delG in two distinct sample sets: an ARHI sample set, composed of 2,311 Caucasian samples from nine different centers originating from seven different countries with an age range between 53 and 67 years, and an NIHL sample set consisting of 702 samples from the two extremes of a noise-exposed Polish sample.Results: After statistical analysis, we were unable to detect an association between 35delG and ARHI, nor between 35delG and NIHL.Conclusion: Our findings indicate that there is no increased susceptibility in 35delG carriers for the development of ARHI or NIHL.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Nyckelord

35delG
Age-related hearing impairment
Complex disorder
Noise-induced hearing loss

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