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The generation of i...
The generation of immune-induced fever and emotional stress-induced hyperthermia in mice does not involve brown adipose tissue thermogenesis
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- Eskilsson, Anna (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Shionoya, Kiseko (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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- Enerbäck, Sven, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Univ Gothenburg, Sweden
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- Engblom, David (författare)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Blomqvist, Anders (författare)
- Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten
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(creator_code:org_t)
- WILEY, 2020
- 2020
- Engelska.
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Ingår i: FASEB Journal. - : WILEY. - 0892-6638 .- 1530-6860. ; 34:4, s. 5863-5876
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- We examined the role of brown adipose tissue (BAT) for fever and emotional stress-induced hyperthermia. Wild-type and uncoupling protein-1 (UCP-1) knockout mice were injected with lipopolysaccharide intraperitoneally or intravenously, or subjected to cage exchange, and body temperature monitored by telemetry. Both genotypes showed similar febrile responses to immune challenge and both displayed hyperthermia to emotional stress. Neither procedure resulted in the activation of BAT, such as the induction of UCP-1 or peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) mRNA, or reduced BAT weight and triglyceride content. In contrast, in mice injected with a beta (3) agonist, UCP-1 and PGC-1 alpha were strongly induced, and BAT weight and triglyceride content reduced. Both lipopolysaccharide and the beta (3) agonist, and emotional stress, induced UCP-3 mRNA in skeletal muscle. A beta (3) antagonist did not attenuate lipopolysaccharide-induced fever, but augmented body temperature decrease and inhibited BAT activation when mice were exposed to cold. An alpha (1)/alpha (2b) antagonist or a 5HT(1A) agonist, which inhibit vasoconstriction, abolished lipopolysaccharide-induced fever, but had no effect on emotional stress-induced hyperthermia. These findings demonstrate that in mice, UCP-1-mediated BAT thermogenesis does not take part in inflammation-induced fever, which is dependent on peripheral vasoconstriction, nor in stress-induced hyperthermia. However, both phenomena may involve UCP-3-mediated muscle thermogenesis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- lipopolysaccharide
- peroxisome proliferator-activated receptor-gamma
- coactivator-1 alpha
- uncoupling protein-1
- uncoupling protein-3
- vasoconstriction
- skeletal-muscle
- nonshivering thermogenesis
- thermoregulatory responses
- uncoupling proteins
- oxygen-consumption
- febrile responses
- body-temperature
- lipopolysaccharide
- receptor
- endotoxin
- Biochemistry & Molecular Biology
- Life Sciences & Biomedicine - Other
- Topics
- Cell Biology
- lipopolysaccharide; peroxisome proliferator-activated receptor-gamma coactivator-1 alpha; uncoupling protein-1; uncoupling protein-3; vasoconstriction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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