SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

L773:1932 6203
 

Sökning: L773:1932 6203 > (2020) > Changes in the vagi...

  • Ahrens, PeterStatens Serum Inst, Denmark (författare)

Changes in the vaginal microbiota following antibiotic treatment forMycoplasma genitalium,Chlamydia trachomatisand bacterial vaginosis

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-07-28
  • PUBLIC LIBRARY SCIENCE,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-168879
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-168879URI
  • https://doi.org/10.1371/journal.pone.0236036DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The human vagina harbor a rich microbiota. The optimal state is dominated by lactobacilli that help to maintain health and prevent various diseases. However, the microbiota may rapidly change to a polymicrobial state that has been linked to a number of diseases. In the present study, the temporal changes of the vaginal microbiota in patients treated for sexually transmitted diseases or bacterial vaginosis (BV) and in untreated controls were studied for 26 days. The patients included 52 women treated with azithromycin, tetracyclines or moxifloxacin for present or suspected infection withChlamydia trachomatisorMycoplasma genitalium. Women with concurrent BV were also treated with metronidazole. The controls were 10 healthy women of matching age. The microbiota was analyzed by 16S rRNA gene deep sequencing, specific qPCRs and microscopy. There was generally good correlation between Nugent score and community state type (CST) and qPCR confirmed the sequencing results. By sequencing, more than 600 different taxa were found, but only 33 constituted more than 1 parts per thousand of the sequences. In both patients and controls the microbiota could be divided into three different community state types, CST-I, CST-III and CST-IV. Without metronidazole, the microbiota remained relatively stable regarding CST although changes were seen during menstrual periods. Administration of metronidazole changed the microbiota from CST-IV to CST-III in approximately 50% of the treated patients. In contrast, the CST was generally unaffected by azithromycin or tetracyclines. In 30% of the BV patients,Gardnerella vaginaliswas not eradicated by metronidazole. The majority of women colonized withUreaplasma parvumremained positive after azithromycin whileU.urealyticumwas eradicated.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Andersen, Lee OBrienStatens Serum Inst, Denmark (författare)
  • Lilje, BeritStatens Serum Inst, Denmark (författare)
  • Johannesen, Thor BechStatens Serum Inst, Denmark (författare)
  • Gomez Dahl, EbbaLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland,Statens Serum Inst, Denmark; Hlth Ctr Gullviksborg, Sweden(Swepub:liu)n/a (författare)
  • Baig, SharminStatens Serum Inst, Denmark (författare)
  • Jensen, Jorgen SkovStatens Serum Inst, Denmark (författare)
  • Falk, LarsLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland(Swepub:liu)larfa68 (författare)
  • Statens Serum Inst, DenmarkInstitutionen för biomedicinska och kliniska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLOS ONE: PUBLIC LIBRARY SCIENCE15:71932-6203

Internetlänk

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy