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Sökning: WFRF:(Winham Stacey J) > Towards defining mo...

  • Ogony, JoshuaMayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)

Towards defining morphologic parameters of normal parous and nulliparous breast tissues by artificial intelligence

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-07-11
  • BMC,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:liu-187409
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-187409URI
  • https://doi.org/10.1186/s13058-022-01541-zDOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|National Institutes of Health [CA RO1 CA229811, R01 CA262393]; Mayo Clinic Comprehensive Cancer Center [P30CA15083-45]
  • Background Breast terminal duct lobular units (TDLUs), the source of most breast cancer (BC) precursors, are shaped by age-related involution, a gradual process, and postpartum involution (PPI), a dramatic inflammatory process that restores baseline microanatomy after weaning. Dysregulated PPI is implicated in the pathogenesis of postpartum BCs. We propose that assessment of TDLUs in the postpartum period may have value in risk estimation, but characteristics of these tissues in relation to epidemiological factors are incompletely described. Methods Using validated Artificial Intelligence and morphometric methods, we analyzed digitized images of tissue sections of normal breast tissues stained with hematoxylin and eosin from donors <= 45 years from the Komen Tissue Bank (180 parous and 545 nulliparous). Metrics assessed by AI, included: TDLU count; adipose tissue fraction; mean acini count/TDLU; mean dilated acini; mean average acini area; mean "capillary" area; mean epithelial area; mean ratio of epithelial area versus intralobular stroma; mean mononuclear cell count (surrogate of immune cells); mean fat area proximate to TDLUs and TDLU area. We compared epidemiologic characteristics collected via questionnaire by parity status and race, using a Wilcoxon rank sum test or Fishers exact test. Histologic features were compared between nulliparous and parous women (overall and by time between last birth and donation [recent birth: <= 5 years versus remote birth: > 5 years]) using multivariable regression models. Results Normal breast tissues of parous women contained significantly higher TDLU counts and acini counts, more frequent dilated acini, higher mononuclear cell counts in TDLUs and smaller acini area per TDLU than nulliparas (all multivariable analyses p < 0.001). Differences in TDLU counts and average acini size persisted for > 5 years postpartum, whereas increases in immune cells were most marked <= 5 years of a birth. Relationships were suggestively modified by several other factors, including demographic and reproductive characteristics, ethanol consumption and breastfeeding duration. Conclusions Our study identified sustained expansion of TDLU numbers and reduced average acini area among parous versus nulliparous women and notable increases in immune responses within five years following childbirth. Further, we show that quantitative characteristics of normal breast samples vary with demographic features and BC risk factors.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • de Bel, ThomasRadboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands (författare)
  • Radisky, Derek C.Mayo Clin, FL 32224 USA (författare)
  • Kachergus, JenniferMayo Clin, FL 32224 USA (författare)
  • Thompson, E. AubreyMayo Clin, FL 32224 USA (författare)
  • Degnim, Amy C.Mayo Clin, MN USA (författare)
  • Ruddy, Kathryn J.Mayo Clin, MN USA (författare)
  • Hilton, TracyMayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Stallings-Mann, MelodyMayo Clin, FL 32224 USA (författare)
  • Vachon, CelineMayo Clin, MN USA (författare)
  • Hoskin, Tanya L.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Heckman, Michael G.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Vierkant, Robert A.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • White, Launia J.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Moore, Raymond M.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Carter, JodiMayo Clin, MN USA (författare)
  • Jensen, MatthewMayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Pacheco-Spann, LauraMayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • Henry, Jill E.Indiana Univ Sch Med, IN 46202 USA (författare)
  • Storniolo, Anna MariaIndiana Univ Sch Med, IN 46202 USA (författare)
  • Winham, Stacey J.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA (författare)
  • van der Laak, JeroenLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Klinisk patologi,Radboud Univ Nijmegen, Netherlands(Swepub:liu)jerva26 (författare)
  • Sherman, Mark E.Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USA; Mayo Clin, FL 32224 USA (författare)
  • Mayo Clin, MN 55905 USA; Mayo Clin, FL 32224 USARadboud Univ Nijmegen, Netherlands; Radboud Univ Nijmegen, Netherlands (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Breast Cancer Research: BMC24:11465-54111465-542X

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