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Platelet-Large Cell...
Platelet-Large Cell Ratio and Erythrocyte Sedimentation Rate are Surrogate Predictors of Latent Tuberculosis Infection
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- Selvavinayagam, Sivaprakasam T. (författare)
- Directorate of Public Health and Preventive Medicine
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- Anusree, Adukkadukkam (författare)
- Central University of Tamil Nadu
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- Yong, Yean Kong (författare)
- Xiamen University - Laboratory Centre
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- Frederick, Asha (författare)
- National Tuberculosis Elimination Programme (NTEP)
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- Murali, Lakshmi (författare)
- National Tuberculosis Elimination Programme (NTEP)
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- Kalaivani, Vasudevan (författare)
- Directorate of Public Health and Preventive Medicine - State Public Health Laboratory
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- Aswathy, Bijulal (författare)
- Central University of Tamil Nadu - Department of Infection and Inflammation
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- Rajeshkumar, Manivannan (författare)
- Directorate of Public Health and Preventive Medicine - State Public Health Laboratory
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- Roy, Chitrali Laha (författare)
- Central University of Tamil Nadu
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- Jith, Karishma S. (författare)
- Central University of Tamil Nadu - Department of Infection and Inflammation
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- Gopalan, Natarajan (författare)
- Central University of Tamil Nadu - Department of Epidemiology and Public Health
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- Murugesan, Amudhan (författare)
- Government Theni Medical College - Department of Microbiology
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- Balakrishnan, Pachamuthu (författare)
- Saveetha University - Centre for Infectious Diseases
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- Govindaraj, Sakthivel (författare)
- Emory University - School of Medicine
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- Larsson, Marie, 1966- (författare)
- Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten
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- Byrareddy, Siddappa N. (författare)
- University of Nebraska Medical Center
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- Velu, Vijayakumar (författare)
- Emory University - School of Medicine
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- Shankar, Esaki Muthu (författare)
- Central University of Tamil Nadu - Department of Infection and Inflammation
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- Kannan, Meganathan (författare)
- Central University of Tamil Nadu - Department of Blood and Vascular Biology
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- Raju, Sivadoss (författare)
- Directorate of Public Health and Preventive Medicine - State Public Health Laboratory
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(creator_code:org_t)
- 2024
- Engelska.
- Relaterad länk:
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https://papers.ssrn....
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aims: Prompt detection and treatment of latent tuberculosis infection (LTBI) holds the key to global TB elimination. The lack of an established test for predicting LTBI poses a substantial challenge in disease management. Here, we identified the biochemical and hematological markers of LTBI, and correlated their usefulness to discriminate LTBI from healthy controls. Main Methods: We conducted a cross-sectional investigation and correlated the various biochemical and hematological markers for detecting LTBI among household contacts (HHCs) of TB infection. Our study included 90 individuals – 30 healthy controls, 30 interferon-gamma release assay (IGRA) positive HHCs, and 30 IGRA-negative HHCs. Biomarkers were measured using designated auto analyzers. Key Findings: ESR, MPV, D-dimer, P-LCR, and PDW were significantly higher among LTBI subjects. ESR, PDW, and P-LCR were markedly associated with LTBI. Multivariate analysis showed that either ESR or P-LCR greater than their respective predetermined cut-off values showed higher odds of developing LTBI. Our study demonstrated that ESR and P-LCR are good surrogate markers for diagnosing LTBI. Also, significantly low ferritin in females and MCHC in males belonging to the HHC/IGRA-ve were observed. Significance: The ESR and P-LCR could aid in predicting LTBI among HHCs. Further, the low serum ferritin is associated with TB resisters.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Latent TB
- Biomarkers
- ESR
- P-LCR
- IGRA
- Ferritin
Publikations- och innehållstyp
- vet (ämneskategori)
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- Av författaren/redakt...
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Selvavinayagam, ...
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Anusree, Adukkad ...
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Yong, Yean Kong
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Frederick, Asha
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Murali, Lakshmi
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Kalaivani, Vasud ...
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visa fler...
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Aswathy, Bijulal
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Rajeshkumar, Man ...
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Roy, Chitrali La ...
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Jith, Karishma S ...
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Gopalan, Nataraj ...
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Murugesan, Amudh ...
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Balakrishnan, Pa ...
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Govindaraj, Sakt ...
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Larsson, Marie, ...
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Byrareddy, Sidda ...
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Velu, Vijayakuma ...
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Shankar, Esaki M ...
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Kannan, Meganath ...
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Raju, Sivadoss
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
- Av lärosätet
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Linköpings universitet