Tyck till om SwePub Sök
här!
Sökning: swepub >
Long-Term Follow-Up...
Long-Term Follow-Up of a Pilot Study Using Placenta-Derived Decidua Stromal Cells for Severe Acute Graft-versus-Host Disease
-
- Sadeghi, Behnam (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, CLINTEC, Translat Cell Therapy Res, Huddinge, Sweden
-
- Remberger, Mats, Professor, 1955- (författare)
- Uppsala universitet,Hematologi,Uppsala Univ Hosp, Klin Forsknings & Utvecklingsenheten Verksamhetso, Uppsala, Sweden
-
- Gustafsson, Britt (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Karolinska Inst, Div Pediat,CLINTEC, Huddinge, Sweden
-
visa fler...
-
- Winiarski, Jacek (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Karolinska Inst, Div Pediat,CLINTEC, Huddinge, Sweden
-
- Moretti, Gianluca (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, CLINTEC, Translat Cell Therapy Res, Huddinge, Sweden
-
- Khoein, Bita (författare)
- Karolinska Inst, Dept Clin Sci Intervent & Technol, CLINTEC, Translat Cell Therapy Res, Huddinge, Sweden
-
- Klingspor, Lena (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Lab Med, Karolinska Inst, Div Clin Microbiol, Stockholm, Sweden
-
- Westgren, Magnus (författare)
- Karolinska Institutet,Karolinska Univ Hosp, CLINTEC, Karolinska Inst, Div Obstet & Gynecol, Stockholm, Sweden
-
- Mattsson, Jonas (författare)
- Karolinska Institutet,Karolinska Inst, Dept Oncol & Pathol, Stockholm, Sweden;Univ Toronto, Princess Margaret Canc Ctr, Div Med Oncol & Hematol, Toronto, ON, Canada
-
- Ringdén, Olle (författare)
- Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, CLINTEC, Translat Cell Therapy Res, Huddinge, Sweden
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- Engelska.
-
Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 54, s. 300-300
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
http://www.bbmt.org/...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
http://kipublication...
-
http://kipublication...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- There is a need for effective therapy with few side effects for severe acute graft-versus-host disease (GVHD). The placenta protects the fetus from the mother's haploidentical immune system during pregnancy. We found that maternal stromal cells from the fetal membrane, so-called decidua stromal cells (DSCs), are more immunosuppressive than other sources of stromal cells. We prospectively treated 21 patients (median age, 49 years; range, 1.6 to 72 years) for grade II-IV acute GVHD. All 21 patients had biopsy-proven gastrointestinal GVHD. The majority of patients were either steroid-refractory or had progressive GVHD, 11 patients after >7 days or with progression after 3 days, and 10 were refractory to steroids after >3 days. We used an improved protocol in which DSCs were thawed and infused in a buffer with 5% human albumin. DSCs were given at a median dose of 1.2 (range, 0.9 to 2.9) x 10(6) cells/kg body weight with a median of 2 (range, 1 to 6) doses, given 1 week apart. The median viability of thawed DSCs was 93% (range, 69% to 100%), and the median cell passage number was 4 (range, 2 to 4). Complete resolution of GVHD was seen in 11 patients, with a partial response in the other 10. The cumulative incidence of chronic GVHD was 52%. GVHD was mild in 6 patients, moderate in 4 patients, and severe in 1 patient based on National Institutes of Health chronic GVHD severity scoring. Nine patients died, including 3 from relapse and 1 each from acute GVHD and septicemia, Zygomycetes infection, liver insufficiency, cerebral hemorrhage, multiple organ failure, and chronic GVHD with obstructive bronchiolitis. Four-year transplantation-related mortality was 28.6%, and overall survival was 57%. Survival was similar (P= .33) to that for all 293 patients who underwent allogeneic hematopoietic cell transplantation during the same period (2012 to 2015), with 66% overall survival. DSC infusion is a novel therapy for acute GVHD grade II-IV, and a randomized trial is currently underway.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Decidua stromal cells
- Graft-versus-host disease
- Long-term follow-up
- Steroid-resistant GVHD
- Survival
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Sadeghi, Behnam
-
Remberger, Mats, ...
-
Gustafsson, Brit ...
-
Winiarski, Jacek
-
Moretti, Gianluc ...
-
Khoein, Bita
-
visa fler...
-
Klingspor, Lena
-
Westgren, Magnus
-
Mattsson, Jonas
-
Ringdén, Olle
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Biology of blood ...
-
CYTOTHERAPY
-
BONE MARROW TRAN ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet