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An evaluation of th...
An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population
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- Tehua Lu, Timothy (författare)
- University of Kiel
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- Lao, Oscar (författare)
- Erasmus University
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- Nothnagel, Michael (författare)
- University of Kiel
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- Junge, Olaf (författare)
- University of Kiel
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- Freitag-Wolf, Sandra (författare)
- University of Kiel
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- Caliebe, Amke (författare)
- University of Kiel
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- Balascakova, Miroslava (författare)
- Charles University of Prague
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- Bertranpetit, Jaume (författare)
- University of Pompeu Fabra
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- Albert Bindoff, Laurence (författare)
- Haukeland Hospital
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- Comas, David (författare)
- University of Pompeu Fabra
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- Holmlund, Gunilla (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Kouvatsi, Anastasia (författare)
- Aristotle University of Thessaloniki
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- Macek, Milan (författare)
- Charles University of Prague
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- Mollet, Isabelle (författare)
- EFS RA Site Lyon
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- Nielsen, Finn (författare)
- University of Copenhagen
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- Parson, Walther (författare)
- Medical University of Innsbruck
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- Palo, Jukka (författare)
- University of Helsinki
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- Ploski, Rafal (författare)
- Warsaw Medical University
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- Sajantila, Antti (författare)
- University of Helsinki
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- Tagliabracci, Adriano (författare)
- University of Ancona
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- Gether, Ulrik (författare)
- University of Copenhagen
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- Werge, Thomas (författare)
- Copenhagen University Hospital
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- Rivadeneira, Fernando (författare)
- Erasmus University
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- Hofman, Albert (författare)
- Erasmus University
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- Gerardus Uitterlinden, Andre (författare)
- Erasmus University
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- Gieger, Christian (författare)
- German Research Centre for Environmental Health
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- Wichmann, Heinz-Erich (författare)
- German Research Centre for Environmental Health
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- Ruether, Andreas (författare)
- University of Kiel
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- Schreiber, Stefan (författare)
- University of Kiel
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- Becker, Christian (författare)
- University of Cologne
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- Nuernberg, Peter (författare)
- University of Cologne
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- Roberts Nelson, Matthew (författare)
- GlaxoSmithKline Inc
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- Kayser, Manfred (författare)
- Erasmus University
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- Krawczak, Michael (författare)
- University of Kiel
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(creator_code:org_t)
- 2009-01-21
- 2009
- Engelska.
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Ingår i: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 17:7, s. 967-975
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Genetic matching potentially provides a means to alleviate the effects of incomplete Mendelian randomization in population-based gene-disease association studies. We therefore evaluated the genetic-matched pair study design on the basis of genome-wide SNP data (309 790 markers; Affymetrix GeneChip Human Mapping 500K Array) from 2457 individuals, sampled at 23 different recruitment sites across Europe. Using pair-wise identity-by-state (IBS) as a matching criterion, we tried to derive a subset of markers that would allow identification of the best overall matching (BOM) partner for a given individual, based on the IBS status for the subset alone. However, our results suggest that, by following this approach, the prediction accuracy is only notably improved by the first 20 markers selected, and increases proportionally to the marker number thereafter. Furthermore, in a considerable proportion of cases (76.0%), the BOM of a given individual, based on the complete marker set, came from a different recruitment site than the individual itself. A second marker set, specifically selected for ancestry sensitivity using singular value decomposition, performed even more poorly and was no more capable of predicting the BOM than randomly chosen subsets. This leads us to conclude that, at least in Europe, the utility of the genetic-matched pair study design depends critically on the availability of comprehensive genotype information for both cases and controls. European Journal of Human Genetics (2009) 17, 967-975; doi:10.1038/ejhg.2008.266; published online 21 January 2009
Nyckelord
- population structure; matching; association; ancestry; microarray
- TECHNOLOGY
- TEKNIKVETENSKAP
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- ref (ämneskategori)
- art (ämneskategori)
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Tehua Lu, Timoth ...
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Lao, Oscar
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Nothnagel, Micha ...
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Junge, Olaf
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Freitag-Wolf, Sa ...
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Caliebe, Amke
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visa fler...
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Balascakova, Mir ...
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Bertranpetit, Ja ...
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Albert Bindoff, ...
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Comas, David
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Holmlund, Gunill ...
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Kouvatsi, Anasta ...
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Macek, Milan
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Mollet, Isabelle
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Nielsen, Finn
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Parson, Walther
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Palo, Jukka
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Ploski, Rafal
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Sajantila, Antti
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Tagliabracci, Ad ...
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Gether, Ulrik
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Werge, Thomas
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Rivadeneira, Fer ...
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Hofman, Albert
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Gerardus Uitterl ...
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Gieger, Christia ...
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Wichmann, Heinz- ...
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Ruether, Andreas
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Schreiber, Stefa ...
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Becker, Christia ...
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Nuernberg, Peter
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Roberts Nelson, ...
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Kayser, Manfred
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Krawczak, Michae ...
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Linköpings universitet