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Celiac disease and complement activation in response to Streptococcus pneumoniae
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- Tjernberg, Anna Rockert (författare)
- Region Kalmar, Sweden;Örebro University, Sweden,Department of Pediatrics, Kalmar County Hospital, Kalmar, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden,Kalmar Cty Hosp, Dept Pediat, Kalmar, Sweden; Örebro Univ, Sch Med Sci, Örebro, Sweden
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- Woksepp, Hanna (författare)
- Region Kalmar, Sweden,Research section, Department of Development and Public Health, Kalmar County Hospital, Kalmar, Sweden,Kalmar Cty Hosp, Dept Dev & Publ Hlth, Res Sect, Kalmar, Sweden
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- Sandholm, Kerstin (författare)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),Linnaeus Ctr Biomat Chem, BMC,Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden,Linnaeus Univ, Linnaeus Ctr Biomat Chem, Kalmar, Sweden
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- (creator_code:org_t)
- 2019-11-05
- 2020
- Engelska.
- Ingår i: European Journal of Pediatrics. - : Springer. - 0340-6199 .- 1432-1076. ; 179:1, s. 133-140
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Individuals with celiac disease (CD) are at increased risk of invasive pneumococcal disease (IPD). The aim of this study was to explore whether the complement response to Streptococcus pneumoniae differed according to CD status, and could serve as an explanation for the excess risk of IPD in CD. Twenty-two children with CD and 18 controls, born 1999-2008, were included at Kalmar County Hospital, Sweden. The degree of complement activation was evaluated by comparing levels of activation products C3a and sC5b-9 in plasma incubated for 30 min with Streptococcus pneumoniae and in non-incubated plasma. Complement analyses were performed with enzyme-linked immunosorbent assay (ELISA). Pneumococcal stimulation caused a statistically significant increase in C3a as well as sC5b-9 in both children with CD and controls but there was no difference in response between the groups. After incubation, C3a increased on average 4.6 times and sC5b-9 22 times in both the CD and the control group (p = 0.497 and p = 0.724 respectively). Conclusion: Complement response to Streptococcus pneumoniae seems to be similar in children with and without CD and is thus unlikely to contribute to the increased susceptibility to invasive pneumococcal disease in CD.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Coeliac
- Pneumococcal
- Infection
- Innate immunity
- MBL
- Immunologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- European Journal of Pediatrics (Sök värdpublikationen i LIBRIS)
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