OTTERS: a powerful TWAS framework leveraging summary-level reference data

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: WFRF:(Ahsan Habibul) > OTTERS: a powerful ...

Dai, QileDepartment of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA (författare)

OTTERS: a powerful TWAS framework leveraging summary-level reference data

Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

Springer Nature,2023
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:ltu-96339
https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-96339URI
https://doi.org/10.1038/s41467-023-36862-wDOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Godkänd;2023;Nivå 0;2023-04-06 (hanlid);Funder: for more funders see the article https://doi.org/10.1038/s41467-023-36862-w
Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
Medical Engineering
Medicinsk teknik

Biuppslag (personer, institutioner, konferenser, titlar ...)

Zhou, GeyuProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA (författare)
Zhao, HongyuProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA (författare)
Võsa, UrmoEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Franke, LudeDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands (författare)
Battle, AlexisDepartment of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA (författare)
Teumer, AlexanderInstitute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany (författare)
Lehtimäki, TerhoDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Centre for Cardiovascular Disease Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland (författare)
Raitakari, Olli T.Centre for Population Health Research, University of Turku and Turku University Hospital, 20520, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland (författare)
Esko, TõnuEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Agbessi, MawusséComputational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada (författare)
Ahsan, HabibulDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA (författare)
Alves, IsabelComputational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada (författare)
Andiappan, Anand KumarSingapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore (författare)
Arindrarto, WibowoLeiden University Medical Center, Leiden, The Netherlands (författare)
Awadalla, PhilipComputational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada (författare)
Battle, AlexisInstitute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany (författare)
Beutner, FrankHeart Center Leipzig, Universität Leipzig, Leipzig, Germany (författare)
Jan Bonder, MarcDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany (författare)
Boomsma, Dorret I.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (författare)
Christiansen, Mark W.Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA (författare)
Claringbould, AnniqueDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands (författare)
Deelen, PatrickDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands; Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands; Department of Genetics, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands (författare)
Favé, Marie-JulieComputational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada (författare)
Frayling, TimothyGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK (författare)
Gharib, Sina A.Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA (författare)
Gibson, GregSchool of Biological Sciences, Georgia Tech, Atlanta, GA, USA (författare)
Heijmans, Bastiaan T.Leiden University Medical Center, Leiden, The Netherlands (författare)
Hemani, GibranMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK (författare)
Jansen, RickAmsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (författare)
Kähönen, MikaDepartment of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland (författare)
Kalnapenkis, AnetteEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Kasela, SilvaEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Kettunen, JohannesUniversity of Helsinki, Helsinki, Finland (författare)
Kim, YungilDepartment of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA (författare)
Kirsten, HolgerInstitut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany (författare)
Kovacs, PeterIFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany (författare)
Krohn, KnutInterdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany (författare)
Kronberg, JaanikaEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Kukushkina, ViktorijaEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Kutalik, ZoltanLausanne University Hospital, Lausanne, Switzerland (författare)
Lee, BernettSingapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore (författare)
Loeffler, MarkusInstitut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany (författare)
Marigorta, Urko M.School of Biological Sciences, Georgia Tech, Atlanta, GA, USA; Integrative Genomics Lab, CIC bioGUNE, Bizkaia Science and Technology Park, Derio, Bizkaia, Basque Country, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain (författare)
Mei, HailangDepartment of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands (författare)
Milani, LiliEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Montgomery, Grant W.Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia (författare)
Müller-Nurasyid, MartinaInstitute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (författare)
Nauck, MatthiasInstitute of Clinical Chemistry and Laboratory Medicine, Greifswald University Hospital, Greifswald, Germany; German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany (författare)
Nivard, Michel G.Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, VU, Amsterdam, The Netherlands (författare)
Penninx, BrendaAmsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (författare)
Perola, MarkusNational Institute for Health and Welfare, University of Helsinki, Helsinki, Finland (författare)
Pervjakova, NataliaEstonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia (författare)
Pierce, Brandon L.Department of Public Health Sciences, University of Chicago, Chicago, IL, USA (författare)
Powell, JosephGarvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, NSW, Australia (författare)
Prokisch, HolgerInstitute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technical University Munich, Munich, Germany (författare)
Psaty, Bruce M.Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA (författare)
Ripatti, SamuliStatistical and Translational Genetics, University of Helsinki, Helsinki, Finland (författare)
Rotzschke, OlafSingapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore (författare)
Rüeger, SinaLausanne University Hospital, Lausanne, Switzerland (författare)
Saha, AshisDepartment of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA (författare)
Scholz, MarkusInstitut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany (författare)
Schramm, KatharinaInstitute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany (författare)
Seppälä, IlkkaDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Centre for Cardiovascular Disease Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland (författare)
Slagboom, Eline P.Leiden University Medical Center, Leiden, The Netherlands (författare)
Stehouwer, Coen D. A.Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands (författare)
Stumvoll, MichaelDepartment of Medicine, Universität Leipzig, Leipzig, Germany (författare)
Sullivan, PatrickDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (författare)
‘t Hoen, Peter A. C.Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands (författare)
Thiery, JoachimInstitute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany (författare)
Tong, LinDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA (författare)
Tönjes, AnkeGerman Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany (författare)
van Dongen, JennyDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (författare)
van Iterson, MaartenLeiden University Medical Center, Leiden, The Netherlands (författare)
van Meurs, JoyceDepartment of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands (författare)
Veldink, Jan H.UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, The Netherlands (författare)
Verlouw, JoostDepartment of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands (författare)
Visscher, Peter M.Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia (författare)
Völker, UweInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany (författare)
Westra, Harm-JanDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands (författare)
Wijmenga, CiscaDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands (författare)
Yaghootkar, HaniehLuleå tekniska universitet,Medicinsk vetenskap,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK; School of Life Sciences, College of Liberal Arts and Science, University of Westminster, 115 New Cavendish Street, London, UK(Swepub:ltu)hanyag (författare)
Yang, JianInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China (författare)
Zeng, BiaoSchool of Biological Sciences, Georgia Tech, Atlanta, GA, USA (författare)
Zhang, FutaoInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia (författare)
Epstein, Michael P.Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA (författare)
Yang, JingjingCenter for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA (författare)
Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USAProgram of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA (creator_code:org_t)

Sammanhörande titlar

Ingår i:Nature Communications: Springer Nature14:12041-1723

Internetlänk

Hitta via bibliotek

Nature Communications (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Dai, Qile; Zhou, Geyu; Zhao, Hongyu; Võsa, Urmo; Franke, Lude; Battle, Alexis; visa fler...; Teumer, Alexande ...; Lehtimäki, Terho; Raitakari, Olli ...; Esko, Tõnu; Agbessi, Mawussé; Ahsan, Habibul; Alves, Isabel; Andiappan, Anand ...; Arindrarto, Wibo ...; Awadalla, Philip; Beutner, Frank; Jan Bonder, Marc; Boomsma, Dorret ...; Christiansen, Ma ...; Claringbould, An ...; Deelen, Patrick; Favé, Marie-Juli ...; Frayling, Timoth ...; Gharib, Sina A.; Gibson, Greg; Heijmans, Bastia ...; Hemani, Gibran; Jansen, Rick; Kähönen, Mika; Kalnapenkis, Ane ...; Kasela, Silva; Kettunen, Johann ...; Kim, Yungil; Kirsten, Holger; Kovacs, Peter; Krohn, Knut; Kronberg, Jaanik ...; Kukushkina, Vikt ...; Kutalik, Zoltan; Lee, Bernett; Loeffler, Markus; Marigorta, Urko ...; Mei, Hailang; Milani, Lili; Montgomery, Gran ...; Müller-Nurasyid, ...; Nauck, Matthias; Nivard, Michel G ...; Penninx, Brenda; Perola, Markus; Pervjakova, Nata ...; Pierce, Brandon ...; Powell, Joseph; Prokisch, Holger; Psaty, Bruce M.; Ripatti, Samuli; Rotzschke, Olaf; Rüeger, Sina; Saha, Ashis; Scholz, Markus; Schramm, Kathari ...; Seppälä, Ilkka; Slagboom, Eline ...; Stehouwer, Coen ...; Stumvoll, Michae ...; Sullivan, Patric ...; ‘t Hoen, Peter A ...; Thiery, Joachim; Tong, Lin; Tönjes, Anke; van Dongen, Jenn ...; van Iterson, Maa ...; van Meurs, Joyce; Veldink, Jan H.; Verlouw, Joost; Visscher, Peter ...; Völker, Uwe; Westra, Harm-Jan; Wijmenga, Cisca; Yaghootkar, Hani ...; Yang, Jian; Zeng, Biao; Zhang, Futao; Epstein, Michael ...; Yang, Jingjing; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

Artiklar i publikationen: Nature Communica ...

Av lärosätet: Luleå tekniska universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se