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Sökning: L773:0007 0920 OR L773:1532 1827 > (2005-2009) > Mälardalens universitet > Interleukin-1 recep...

  • Lindmark, FUmeå universitet,Onkologi (författare)

Interleukin-1 receptor antagonist haplotype associated with prostate cancer risk

  • Artikel/kapitelEngelska2005

Förlag, utgivningsår, omfång ...

  • 2005-08-02
  • Umea Univ, Dept Radiat Sci Oncol, S-90187 Umea, Sweden. Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Univ Hosp, Reg Oncol Ctr, Uppsala, Sweden.NATURE PUBLISHING GROUP,2005
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:mdh-40726
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40726URI
  • https://doi.org/10.1038/sj.bjc.6602729DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-14460URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1935291URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • IL1-RN is an important anti-inflammatory cytokine that modulate the inflammation response by binding to IL1 receptors, and as a consequence inhibits the action of proinflammatory cytokines IL1 alpha and IL1 beta. In this study, we hypothesise that sequence variants in the IL1-RN gene are associated with prostate cancer risk. The study population, a population-based case - control study in Sweden, consisted of 1383 prostate cancer case patients and 779 control subjects. We first selected 18 sequence variants covering the IL1-RN gene and genotyped these single-nucleotide polymorphisms ( SNPs) in 96 control subjects. Gene-specific haplotypes of IL1-RN were constructed and four haplotype-tagging single-nucleotide polymorphisms (htSNPs) were identified (rs878972, rs315934, rs3087263 and rs315951) that could uniquely describe 495% of the haplotypes. All study subjects were genotyped for the four htSNPs. No significant difference in genotype frequencies between cases and controls were observed for any of the four SNPs based on a multiplicative genetic model. Overall there was no significant difference in haplotype frequencies between cases and controls; however, the prevalence of the most common haplotype (ATGC) was significantly higher among cases (38.7%) compared to controls (33.5%) ( haplotype-specific P = 0.009). Evaluation of the prostate cancer risk associated with carrying the 'ATGC' haplotype revealed that homozygous carriers were at significantly increased risk ( odds ratio (OR) = 1.6, 95% confidence interval (CI) = 1.2 - 2.2), compared to noncarriers, while no significant association was found among subjects heterozygous for the haplotype ( OR = 1.0, 95% CI = 0.8 - 1.2). Restricting analyses to advanced prostate cancer strengthened the association between the 'ATGC' haplotype and disease risk (OR for homozygous carriers vs noncarriers 1.8, 95% CI = 1.3 - 2.5). In conclusion, the results from this study support the hypothesis that inflammation has a role of in the development of prostate cancer, but further studies are needed to identify the causal variants in this region and to elucidate the biological mechanism for this association.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zheng, S L (författare)
  • Wiklund, FKarolinska Institutet,Umeå universitet,Onkologi (författare)
  • Bälter Augustsson, KatarinaKarolinska Institutet(Swepub:mdh)kbr01 (författare)
  • Sun, J (författare)
  • Chang, B (författare)
  • Hedelin, MKarolinska Institutet (författare)
  • Clark, J (författare)
  • Johansson, J E (författare)
  • Meyers, D A (författare)
  • Adami, H OKarolinska Institutet (författare)
  • Isaacs, W (författare)
  • Gronberg, HKarolinska Institutet,Umeå universitet,Onkologi (författare)
  • Xu, J (författare)
  • Umeå universitetOnkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:British Journal of CancerUmea Univ, Dept Radiat Sci Oncol, S-90187 Umea, Sweden. Wake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Johns Hopkins Med Inst, Dept Urol, Baltimore, MD 21205 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Univ Hosp, Reg Oncol Ctr, Uppsala, Sweden. : NATURE PUBLISHING GROUP93:4, s. 493-4970007-09201532-1827

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