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  • Papakokkinou, EleniGothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition (author)

Excess Morbidity Persists in Patients With Cushing’s Disease During Long-term Remission : A Swedish Nationwide Study

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-05-21
  • Washington :Oxford University Press,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-108764
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108764URI
  • https://doi.org/10.1210/clinem/dgaa291DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175455URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421529URI
  • https://lup.lub.lu.se/record/d68ede31-b1b3-4360-8d7a-1ff211ae88acURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170002URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144570481URI
  • https://gup.ub.gu.se/publication/293536URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:county councils, the ALF-agreementGothenburg Society of Medicine
  • Funding Agencies|Swedish government [ALFGBG-593301]; county councils, the ALF-agreement [ALFGBG-593301]; Gothenburg Society of Medicine
  • Context: Whether multisystem morbidity in Cushing's disease (CD) remains elevated during long-term remission is still undetermined.Objective: To investigate comorbidities in patients with CD.Design, setting, and patients: A retrospective, nationwide study of patients with CD identified in the Swedish National Patient Register between 1987 and 2013. Individual medical records were reviewed to verify diagnosis and remission status.Main outcomes: Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated by using the Swedish general population as reference. Comorbidities were investigated during three different time periods: (i) during the 3 years before diagnosis, (ii) from diagnosis to 1 year after remission, and (iii) during long-term remission.Results: We included 502 patients with confirmed CD, of whom 419 were in remission for a median of 10 (interquartile range 4 to 21) years. SIRs (95% CI) for myocardial infarction (4.4; 1.2 to 11.4), fractures (4.9; 2.7 to 8.3), and deep vein thrombosis (13.8; 3.8 to 35.3) were increased during the 3-year period before diagnosis. From diagnosis until 1 year after remission, SIRs (95% CI were increased for thromboembolism (18.3; 7.9 to 36.0), stroke (4.9; 1.3 to 12.5), and sepsis (13.6; 3.7 to 34.8). SIRs for thromboembolism (4.9; 2.6 to 8.4), stroke (3.1; 1.8 to 4.9), and sepsis (6.0; 3.1 to 10.6) remained increased during long-term remission.Conclusion: Patients with CD have an increased incidence of stroke, thromboembolism, and sepsis even after remission, emphasizing the importance of early identification and management of risk factors for these comorbidities during long-term follow-up.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Olsson, Daniel S,1983Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xolssd (author)
  • Chantzichristos, Dimitrios,1976Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xchadi (author)
  • Dahlqvist, PerUmeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, SE-90187 Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)perdat96 (author)
  • Segerstedt, ElinUmeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, SE-90187 Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden (author)
  • Olsson, TommyUmeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, SE-90187 Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden(Swepub:umu)tool0003 (author)
  • Petersson, MariaKarolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden (author)
  • Berinder, KatarinaKarolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden (author)
  • Bensing, SophieKarolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden (author)
  • Höybye, CharlotteKarolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden (author)
  • Engström, Britt EUppsala universitet,Endokrinologi och mineralmetabolism,Department of Medical Sciences; Endocrinology, Diabetes and Metabolism, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)brittee (author)
  • Burman, PiaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,Department of Medical Sciences; Endocrinology, Diabetes and Metabolism, Uppsala University Hospital, Uppsala, Sweden(Swepub:lu)med-bap (author)
  • Bonelli, LorenzaDepartment of Endocrinology, Skåne University Hospital, University of Lund, Malmö, Sweden,Lund Univ, Skane Univ Hosp, Dept Endocrinol, SE-20502 Malmö, Sweden. (author)
  • Follin, CeciliaDepartment of Endocrinology, Skåne University Hospital, Lund, Sweden,Skåne Univ Hosp, Dept Endocrinol, SE-22242 Lund, Sweden.(Swepub:lu)med-cfn (author)
  • Petranek, DavidDepartment of Endocrinology, Skåne University Hospital, Lund, Sweden,Skåne Univ Hosp, Dept Endocrinol, SE-22242 Lund, Sweden. (author)
  • Erfurth, Eva MarieDepartment of Endocrinology, Skåne University Hospital, Lund, Sweden,Skåne Univ Hosp, Dept Endocrinol, SE-22242 Lund, Sweden.(Swepub:lu)med-ee0 (author)
  • Wahlberg, Jeanette,1969-Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)jeawa98 (author)
  • Ekman, Bertil,1958-Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)berek83 (author)
  • Åkerman, Anna-KarinKarolinska Institutet,Örebro University,Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden (author)
  • Schwarcz, ErikÖrebro University,Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden (author)
  • Bryngelsson, Ing-LissÖrebro University,Department of Occupational and Environmental Medicine, University Hospital, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (author)
  • Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xjgudn (author)
  • Ragnarsson, Oskar,1971Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xragos (author)
  • University of GothenburgDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and MetabolismWashington : Oxford University Press105:8, s. 2616-26240021-972X1945-7197

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