Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska grundvetenskaper Fysiologi) > Uppsala universitet > Alterations in the ...

Eliason, Gabriella,1975-Örebro universitet,Hälsoakademin (författare)

Alterations in the muscle-to-capillary interface in patients with different degrees of chronic obstructive pulmonary disease

Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

2010-07-15
London, United Kingdom :BioMed Central,2010
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:oru-12493
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-12493URI
https://doi.org/10.1186/1465-9921-11-97DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134332URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Background: It is hypothesized that decreased capillarization of limb skeletal muscle is implicated in the decreased exercise tolerance in COPD patients. We have recently demonstrated decreased number of capillaries per muscle fibre (CAF) but no changes in CAF in relation to fibre area (CAFA), which is based on the diffusion distance between the capillary and muscle fibre. The aim of the current study is to investigate the muscle-to-capillary interface which is an important factor involved in oxygen supply to the muscle that has previously been suggested to be a more sensitive marker for changes in the capillary bed compared to CAF and CAFA.Methods: 23 COPD patients and 12 age-matched healthy subjects participated in the study. Muscle-to-capillary interface was assessed in muscle biopsies from the tibialis anterior muscle using the following parameters:1) The capillary-to-fibre ratio (C:Fi) which is defined as the sum of the fractional contributions of all capillary contacts around the fibre2) The ratio between C:Fi and the fibre perimeter (CFPE-index)3) The ratio between length of capillary and fibre perimeter (LC/PF) which is also referred to as the index of tortuosity.Exercise capacity was determined using the 6-min walking test. Results: A positive correlation was found between CFPE-index and ascending disease severity with CFPE-index for type I fibres being significantly lower in patients with moderate and severe COPD. Furthermore, a positive correlation was observed between exercise capacity and CFPE-index for both type I and type IIa fibres.Conclusion: It can be concluded that the muscle-to-capillary interface is disturbed in the tibialis anterior muscle in patients with COPD and that interface is strongly correlated to increased disease severity and to decreased exercise capacity in this patient group.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
COPD
muscle-capillary interface
CFPE-index
LC/PF
tortuosity
Physiology
Fysiologi
MEDICINE
MEDICIN
Fysiologi
Physiology
Medicin
Medicine

Biuppslag (personer, institutioner, konferenser, titlar ...)

Abdel-Halim, Samy M.Uppsala universitet,Lungmedicin och allergologi(Swepub:uu)samab850 (författare)
Piehl-Aulin, KarinSchool of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Rheumatology, Danderyds hospital, Stockholm, Sweden(Swepub:oru)knpn (författare)
Kadi, Fawzi,1970-Örebro universitet,Institutionen för hälsovetenskap och medicin,RISPA- MEP-RG(Swepub:oru)fki (författare)
Örebro universitetHälsoakademin (creator_code:org_t)

Sammanhörande titlar

Ingår i:Respiratory ResearchLondon, United Kingdom : BioMed Central111465-99211465-993X

Internetlänk

Hitta via bibliotek

Respiratory Research (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Eliason, Gabriel ...; Abdel-Halim, Sam ...; Piehl-Aulin, Kar ...; Kadi, Fawzi, 197 ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Fysiologi

Artiklar i publikationen: Respiratory Rese ...

Av lärosätet: Örebro universitet; Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se