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Elevated body swing...
Elevated body swing test after focal cerebral ischemia in rodents : methodological considerations
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- Ingberg, Edvin, 1988- (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Diagnostikcentrum
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- Gudjonsdottir, Johanna (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Neurokirurgiska kliniken US
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- Theodorsson, Elvar (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Theodorsson, Annette (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurokirurgiska kliniken US
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- Ström, Jakob O., 1983- (author)
- Linköpings universitet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Division of Microbiology, Linköping University, Linköping, Sweden; Molecular Medicine, Department of Clinical and Experimental Medicine, Department of Clinical Chemistry, Faculty of Health Sciences, Center for Diagnostics, Region Östergötland, Linköping, Sweden; Örebro University Hospital, County Council of Örebro, Centre for Health Sciences (Vårdvetenskapligt Forskningscentrum), Örebro, Sweden,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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(creator_code:org_t)
- 2015-08-05
- 2015
- English.
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In: BMC Neuroscience. - : Springer Science and Business Media LLC. - 1471-2202. ; 16
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Abstract
Subject headings
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- Background: The elevated body swing test (EBST) is a behavioral test used to evaluate experimental stroke in rodents. The basic idea is that when the animal is suspended vertically by the tail, it will swing its head laterally to the left or right depending on lesion side. In a previous study from our lab using the EBST after middle cerebral artery occlusion (MCAo), rats swung contralateral to the infarct day 1 post-MCAo, but ipsilateral day 3 post-MCAo. This shift was unexpected and prompted us to perform the present study. First, the literature was systematically reviewed to elucidate whether a similar shift had been noticed before, and if consensus existed regarding swing direction. Secondly, an experiment was conducted to systematically investigate the suggested behavior. Eighty-three adult male and female Sprague-Dawley rats were subjected to MCAo or sham surgery and the EBST was performed up to 7 days after the lesion.Results: Both experimentally and through systematic literature review, the present study shows that the direction of biased swing activity in the EBST for rodents after cerebral ischemia can differ and even shift over time in some situations. The EBST curve for females was significantly different from that of males after the same occlusion time (p = 0.023).Conclusions: This study highlights the importance of adequate reporting of behavioral tests for lateralization and it is concluded that the EBST cannot be recommended as a test for motor asymmetry after MCAo in rats.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Brain infarction
- Focal cerebral ischemia
- Middle cerebral artery occlusion
- Elevated body swing test
- Rodents
- Rats
- Lateralization
- Neurologi
- Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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