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Sökning: L773:0095 1137 > (2015-2019) > Genomic epidemiolog...

Genomic epidemiology and molecular resistance mechanisms of azithromycin resistant Neisseria gonorrhoeae in Canada from 1997 to 2014

Demczuk, Walter (författare)
Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Martin, Irene (författare)
Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Peterson, Shelley (författare)
Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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Bharat, Amrita (författare)
Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
Van Domselaar, Gary (författare)
Science Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
Graham, Morag (författare)
Science Technology Cores and Services Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
Lefebvre, Brigitte (författare)
Laboratoire de Santé Publique du Québec, Ste-Anne-de-Bellevue QC, Canada
Allen, Vanessa (författare)
Public Health Ontario Laboratories, Toronto ON, Canada
Hoang, Linda (författare)
British Columbia Centres for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver BC, Canada
Tyrrell, Greg (författare)
Provincial Laboratory for Public Health, Edmonton, Canada
Horsman, Greg (författare)
Saskatchewan Disease Control Laboratory, Regina, Canada
Wylie, John (författare)
Cadham Provincial Laboratory, Winnipeg, Canada
Haldane, David (författare)
Queen Elizabeth II Health Sciences Centre, Halifax, Canada
Archibald, Chris (författare)
Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Canada
Wong, Tom (författare)
First Nations and Inuit Health Branch, Health Canada, Ottawa, Canada
Unemo, Magnus, 1970- (författare)
Örebro universitet,Institutionen för hälsovetenskaper,Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Mulvey, Michael R (författare)
Bacteriology and Enteric Diseases Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada
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 (creator_code:org_t)
Washington, USA : American Society for Microbiology, 2016
2016
Engelska.
Ingår i: Journal of Clinical Microbiology. - Washington, USA : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 54:5, s. 1304-1313
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The emergence of Neisseria gonorrhoeae with decreased susceptibility to cephalosporins and azithromycin resistance (AZM-R) represent a public health threat of untreatable gonorrhoea infections. Genomic epidemiology through whole genome sequencing was used to describe the emergence, dissemination, and spread of AZM-R strains. The genomes of 213 AZM-R and 23 AZM-susceptible N. gonorrhoeae isolates collected in Canada from 1989 to 2014 were sequenced. Core single nucleotide polymorphism (SNP) phylogenomic analysis resolved 246 isolates into 13 lineages. High-level AZM-R (minimum inhibitory concentration ≥256 μg/ml) was found in 5 phylogenetically diverse isolates, all of which possessed the A2059G mutation (Escherichia coli numbering) in all four 23S rRNA alleles. One high-level AZM-R isolate collected in 2009 concurrently had decreased susceptibility to ceftriaxone (MIC=0.125 μg/ml). An increase in the number of 23S rRNA alleles with the C2611T mutations (E. coli numbering) conferred low to moderate AZM-R (2 to 4 and 8 to 32 μg/mL, respectively). Low level AZM-R was also associated with mtrR promoter mutations including -35A deletion and the presence of N. meningitidis-like sequences. Geographic and temporal phylogenetic clustering indicate emergent AZM-R strains arise independently and can then rapidly expand clonally in a region through local sexual networks.

Ämnesord

NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)

Nyckelord

Microbiology
Mikrobiologi

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