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  • Ellinghaus, DavidInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany (författare)

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016-03-14
  • New York, USA :Nature Publishing Group,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-49331
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49331URI
  • https://doi.org/10.1038/ng.3528DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:133467000URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:German Federal Ministry of Education and Research (BMBF) 01ZX1306AEstonian Research Council IUT20-60Center of Excellence in Genomics (EXCEGEN)University of Tartu (SP1GVARENG)UK Department of Health via National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre awards to Guy's and St Thomas' National Health Service (NHS) Foundation TrustKing's College LondonUniversity of CambridgeGerman Federal Ministry of Education and Research (BMBF), within the context of National Genome Research Network 2 (NGFN-2)National Genome Research Network plus (NGFNplus)Integrated Genome Research Network (IG) MooDS 01GS08144  01GS08147Netherlands Organization for Scientific Research (NWO) 016.136.308US NIH 1R01AR063759  5U01GM092691-05  1UH2AR067677-01  U19AI111224-01  1R01DK084960-05Doris Duke Charitable Foundation 2013097Novo Nordisk Foundation NNF14CC0001H2020 project MedBioinformatics 634143Norwegian PSC Research Center
  • We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jostins, LukeWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK (författare)
  • Spain, Sarah L.Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK (författare)
  • Cortes, AdrianNuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK (författare)
  • Bethune, JörnInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Han, BuhmDepartment of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea (författare)
  • Park, Yu RangAsan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea (författare)
  • Raychaudhuri, SoumyaProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States (författare)
  • Pouget, Jennie G.Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada (författare)
  • Hübenthal, MatthiasInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Folseraas, TrineNorwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway (författare)
  • Wang, YunpengDepartment of Neurosciences, University of California, San Diego, USA (författare)
  • Esko, TonuEstonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Boston Children's Hospital, Cambridge MA, USA; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, USA (författare)
  • Metspalu, AndresEstonian Genome Center, University of Tartu, Tartu, Estonia (författare)
  • Westra, Harm-JanProgram in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States; Department of Medicine, Harvard Medical School, Boston MA, United States (författare)
  • Franke, LudeUniversity Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, the Netherlands (författare)
  • Pers, Tune H.Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, United States; Novo Nordisk Foundation, Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark (författare)
  • Weersma, Rinse K.Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands (författare)
  • Collij, ValerieDepartment of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands (författare)
  • D'Amato, MauroKarolinska Institutet (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)jshn (författare)
  • Jensen, Anders BoeckNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Lieb, WolfgangInstitute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany; PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany (författare)
  • Degenhardt, FranziskaInstitute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany (författare)
  • Forstner, Andreas J.Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany (författare)
  • Hofmann, AndreaInstitute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany (författare)
  • The International IBD Genetics Consortium, (IIBDGC) (författare)
  • International Genetics of Ankylosing Spondylitis Consortium, (IGAS) (författare)
  • International PSC Study Group, (IPSCSG) (författare)
  • Genetic Analysis of Psoriasis Consortium, (GAPC) (författare)
  • Psoriasis Association Genetics Extension, (PAGE) (författare)
  • Schreiber, StefanInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany (författare)
  • Mrowietz, UlrichDepartment of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Juran, Brian D.Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA (författare)
  • Lazaridis, Konstantinos N.Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA (författare)
  • Brunak, SørenNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
  • Dale, Anders M.Department of Neurosciences, University of California, San Diego, USA; Department of Radiology, University of California, San Diego, USA (författare)
  • Trembath, Richard C.Division of Genetics and Molecular Medicine, King's College London, London, UK (författare)
  • Weidinger, StephanDepartment of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Weichenthal, MichaelDepartment of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Ellinghaus, EvaInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Elder, James T.Department of Dermatology, University of Michigan, Ann Arbor, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, USA (författare)
  • Barker, Jonathan N. W. N.St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK (författare)
  • Andreassen, Ole A.NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital Ullevål, Oslo, Norway (författare)
  • McGovern, Dermot P.F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, USA; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, USA (författare)
  • Karlsen, Tom H.Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway (författare)
  • Barrett, Jeffrey C.Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK (författare)
  • Parkes, MilesInflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK (författare)
  • Brown, Matthew A.University of Queensland Diamantina Institute, Translational Research Institute, Brisbane QLD, Australia; Institute of Health and Biomedical Innovation (IHBI), Translational Research Institute, Queensland University of Technology (QUT), Brisbane QLD, Australia (författare)
  • Franke, AndreInstitute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany (författare)
  • Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, GermanyWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature GeneticsNew York, USA : Nature Publishing Group48:5, s. 510-5181061-40361546-1718

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