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  • Tyekucheva, SvitlanaDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)

Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-09-04
  • London, United Kingdom :Nature Publishing Group,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-64722
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64722URI
  • https://doi.org/10.1038/s41467-017-00460-4DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Challenge award from the Prostate Cancer FoundationProstate Cancer Foundation Irish Cancer Society Wellcome Trust-Health Research Board Dublin Centre for Clinical Research  
  • While progression from normal prostatic epithelium to invasive cancer is driven by molecular alterations, tumor cells and cells in the cancer microenvironment are co-dependent and co-evolve. Few human studies to date have focused on stroma. Here, we performed gene expression profiling of laser capture microdissected normal non-neoplastic prostate epithelial tissue and compared it to non-transformed and neoplastic low-grade and high-grade prostate epithelial tissue from radical prostatectomies, each with its immediately surrounding stroma. Whereas benign epithelium in prostates with and without tumor were similar in gene expression space, stroma away from tumor was significantly different from that in prostates without cancer. A stromal gene signature reflecting bone remodeling and immune-related pathways was upregulated in high compared to low-Gleason grade cases. In validation data, the signature discriminated cases that developed metastasis from those that did not. These data suggest that the microenvironment may influence prostate cancer initiation, maintenance, and metastatic progression.Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bowden, MichaelaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA (författare)
  • Bango, ClydeDepartment of Oncologic Pathology, Dana-Farber Cancer Institute, Boston MA, USA (författare)
  • Giunchi, FrancescaDepartment of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of Bologna, Bologna, Italy (författare)
  • Huang, YingDepartment of Oncologic Pathology, Dana-Farber Cancer Institute, Boston MA, USA (författare)
  • Zhou, ChenshengDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA (författare)
  • Bondi, ArrigoDepartment of Surgical Pathology, Maggiore Hospital, Bologna, Italy (författare)
  • Lis, RosinaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA (författare)
  • Van Hemelrijck, MiekeDivision of Cancer Studies, Translational Oncology, King's College London, London, UK; Urology Research, Guy's Hospital, London, UK (författare)
  • Andrén, Ove,1963-Department of Urology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University Hospital, Örebro, Sweden(Swepub:oru)oan (författare)
  • Andersson, Sven-Olof,1949-Department of Urology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University Hospital, Örebro, Sweden (författare)
  • Watson, R. WilliamSchool of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD), Dublin, Ireland (författare)
  • Pennington, StephenSchool of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland (författare)
  • Finn, Stephen P.Department of Histopathology and Morbid Anatomy, School of Medicine, Trinity College Dublin, Dublin, Ireland (författare)
  • Martin, Neil E.Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA (författare)
  • Stampfer, Meir J.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Parmigiani, GiovanniDepartment of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Penney, Kathryn L.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Fiorentino, MichelangeloDepartment of Pathology, Addarii Institute of Oncology, S.Orsola-Malpighi Teaching Hospital, University of Bologna, Bologna, Italy (författare)
  • Mucci, Lorelei A.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA (författare)
  • Loda, MassimoDepartment of Oncologic Pathology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; The Broad Institute, Cambridge MA, USA (författare)
  • Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USADepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston MA, USA (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nature CommunicationsLondon, United Kingdom : Nature Publishing Group8:12041-1723

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