Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial

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Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial

Gunst, Jesper D. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Staerke, Nina B. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Pahus, Marie H. (författare): Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark

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Kristensen, Lena H. (författare): Deptarment of Medicine, Viborg Regional Hospital, Denmark

Bodilsen, Jacob (författare): Deptarment of Infectious Diseases, Aalborg University Hospital, Denmark

Lohse, Nicolai (författare): Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark; Deptarment of Clinical Medicine, Copenhagen University, Copenhagen, Denmark

Dalgaard, Lars S. (författare): Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark

Brønnum, Dorthe (författare): Centre for Clinical Research, North Denmark Regional Hospital, Hjoerring, Denmark

Fröbert, Ole, 1964- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Dept. of Cardiology

Hønge, Bo (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Internal Medicine, Randers Regional Hospital, Randers, Denmark

Johansen, Isik S. (författare): Research Unit for Infectious Diseases, Odense University Hospital, University of Southern Denmark, Denmark

Monrad, Ida (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Erikstrup, Christian (författare): Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark; Deptarment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark

Rosendal, Regitze (författare): Deptarment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark

Vilstrup, Emil (författare): Deptarment of Medicine, Viborg Regional Hospital, Denmark

Mariager, Theis (författare): Deptarment of Infectious Diseases, Aalborg University Hospital, Denmark

Bove, Dorthe G. (författare): Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark

Offersen, Rasmus (författare): Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark

Shakar, Shakil (författare): Deptarment of Internal Medicine, North Denmark Regional Hospital, Denmark; Deptarment of Emergency Medicine, North Denmark Regional Hospital, Denmark

Cajander, Sara, 1980- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Deptarment of Infectious Diseases

Jørgensen, Nis P. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Internal Medicine, Randers Regional Hospital, Randers, Denmark

Sritharan, Sajitha S. (författare): Deptarment of Medicine, Viborg Regional Hospital, Denmark

Breining, Peter (författare): Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark

Jespersen, Søren (författare): Deptarment of Emergency Medicine, Copenhagen University Hospital, Hillerød, Denmark

Mortensen, Klaus L. (författare): Deptarment of Medicine, Regional Hospital West Jutland, Herning, Denmark

Jensen, Mads L. (författare): Deptarment of Medicine, Viborg Regional Hospital, Denmark

Kolte, Lilian (författare): Deptarment of Lung and Infectious Diseases, Copenhagen University Hospital, Hillerød, Denmark

Frattari, Giacomo S. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Larsen, Carsten S. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Storgaard, Merete (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Nielsen, Lars P. (författare): Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark

Tolstrup, Martin (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark

Sædder, Eva A. (författare): Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Biomedicine, Aarhus University, Aarhus, Denmark

Østergaard, Lars J. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark

Ngo, Hien T. T. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Jensen, Morten H. (författare): Deptarment of Health Science and Technology, Aalborg University, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark

Højen, Jesper F. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark

Kjolby, Mads (författare): Deptarment of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark; DANDRITE, Deptarment of Biomedicine, Aarhus University, Aarhus Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Denmark; University of Dundee, Scotland, United Kingdom

Søgaard, Ole S. (författare): Deptarment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Deptarment of Clinical Medicine, Aarhus University, Aarhus, Denmark

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Elsevier, 2021
2021
Engelska.
Ingår i: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 35

Relaterad länk:: https://doi.org/10.1...; visa fler...; http://www.thelancet...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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Background: The trans-membrane protease serine 2 (TMPRSS2) is essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry and infection. Efficacy and safety of TMPRSS2 inhibitors in patients with coronavirus disease 2019 (Covid-19) have not been evaluated in randomized trials.Methods: We conducted an investigator-initiated, double-blind, randomized, placebo-controlled multicenter trial in patients hospitalized with confirmed SARS-CoV-2 infection from April 4, to December 31, 2020. Within 48 h of admission, participants were randomly assigned in a 2:1 ratio to receive the TMPRSS2 inhibitor camostat mesilate 200 mg three times daily for 5 days or placebo. The primary outcome was time to discharge or clinical improvement measured as ≥2 points improvement on a 7-point ordinal scale. Other outcomes included 30-day mortality, safety and change in oropharyngeal viral load. ClinicalTrials.gov Identifier: NCT04321096. EudraCT Number: 2020-001,200-42.Findings: 137 patients were assigned to receive camostat mesilate and 68 to placebo. Median time to clinical improvement was 5 days (interquartile range [IQR], 3 to 7) in the camostat group and 5 days (IQR, 2 to 10) in the placebo group (P = 0·31). The hazard ratio for 30-day mortality in the camostat compared with the placebo group was 0·82 (95% confidence interval [CI], 0·24 to 2·79; P = 0·75). The frequency of adverse events was similar in the two groups. Median change in viral load from baseline to day 5 in the camostat group was -0·22 log10 copies/mL (p <0·05) and -0·82 log10 in the placebo group (P <0·05).Interpretation: Under this protocol, camostat mesilate treatment was not associated with increased adverse events during hospitalization for Covid-19 and did not affect time to clinical improvement, progression to ICU admission or mortality.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Örebro universitet

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Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial

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