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Regional and temporal differences in the associations between cardiovascular disease and its classic risk factors : an analysis of 49 cohorts from 11 European countries

Reinikainen, Jaakko (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), P.O. Box 30, Helsinki, Finland
Kuulasmaa, Kari (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), P.O. Box 30, Helsinki, Finland
Oskarsson, Viktor (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Amouyel, Philippe (författare)
Inserm, Institut Pasteur de Lille, Lille, France
Biasch, Katia (författare)
Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, Germany
De Ponti, Roberto (författare)
Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
Donfrancesco, Chiara (författare)
Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
Drygas, Wojciech (författare)
Department of Epidemiology, Cardiovascular Disease Prevention and Heart Promotion, National Institute of Cardiology, Warsaw, Poland; Faculty of Medicine, Lazarski University, Warsaw, Poland
Ferrieres, Jean (författare)
Department of Cardiology, Inserm Umr 1027, Toulouse University School of Medicine, Rangueil Hospital, Toulous, France
Grassi, Guido (författare)
Clinica Medica, University of Milano-Bicocca, Milan, Italy
Grimsgaard, Sameline (författare)
Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
Iacoviello, Licia (författare)
Department of Epidemiology and Prevention, Irccs Neuromed, Pozzilli, Italy; Research Center in Epidemiology and Preventive Medicine-EPIMED, Department of Medicine and Surgery, University of Insubria, Varese, Italy
Jousilahti, Pekka (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), P.O. Box 30, Helsinki, Finland
Kårhus, Line L. (författare)
Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark
Kee, Frank (författare)
Centre for Public Health, The Queen's University of Belfast, Belfast, United Kingdom
Linneberg, Allan (författare)
Center for Clinical Research and Prevention, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Luksiene, Dalia (författare)
Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Mariño, Joany (författare)
Unit Quality in the Health Sciences (QIHS), Department SHIP-KEF, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Moitry, Marie (författare)
Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France
Palmieri, Luigi (författare)
Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy
Peters, Annette (författare)
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Cardiovascular Disease Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany
Piwonska, Aleksandra (författare)
Department of Epidemiology, Cardiovascular Disease Prevention and Heart Promotion, National Institute of Cardiology, Warsaw, Poland
Quarti-Trevano, Fosca (författare)
Clinica Medica, University of Milano-Bicocca, Milan, Italy
Salomaa, Veikko (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), P.O. Box 30, Helsinki, Finland
Sans, Susana (författare)
Catalan Department of Health, Barcelona, Spain
Schmidt, Carsten Oliver (författare)
Unit Quality in the Health Sciences (QIHS), Department SHIP-KEF, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
Schöttker, Ben (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Network Aging Research, Heidelberg University, Heidelberg, Germany
Söderberg, Stefan (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Tamosiunas, Abdonas (författare)
Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania
Thorand, Barbara (författare)
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany
Tunstall-Pedoe, Hugh (författare)
Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee, United Kingdom
Vanuzzo, Diego (författare)
MONICA-FRIULI Study Group, Udine, Italy
Veronesi, Giovanni (författare)
Research Center in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Varese, Italy
Woodward, Mark (författare)
The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, Sydney, Australia
Lekadir, Karim (författare)
Artifcial Intelligence in Medicine Lab (BCN AIM), Departament de Matemàtiques i Informàtica, Universitat de Barcelona, Barcelona, Spain
Niiranen, Teemu (författare)
Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), P.O. Box 30, Helsinki, Finland; Department of Internal Medicine, University of Turku, Turku University Hospital, Turku, Finland
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Department of Public Health and Welfare, Finnish Institute for Health and Welfare (THL), PO. Box 30, Helsinki, Finland Institutionen för folkhälsa och klinisk medicin (creator_code:org_t)
Oxford University Press, 2024
2024
Engelska.
Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press. - 2047-4873 .- 2047-4881. ; 31:5, s. 569-577
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims: The regional and temporal differences in the associations between cardiovascular disease (CVD) and its classic risk factors are unknown. The current study examined these associations in different European regions over a 30-year period.Methods and results: The study sample comprised 553 818 individuals from 49 cohorts in 11 European countries (baseline: 1982-2012) who were followed up for a maximum of 10 years. Risk factors [sex, smoking, diabetes, non-HDL cholesterol, systolic blood pressure (BP), and body mass index (BMI)] and CVD events (coronary heart disease or stroke) were harmonized across cohorts. Risk factor-outcome associations were analysed using multivariable-adjusted Cox regression models, and differences in associations were assessed using meta-regression. The differences in the risk factor-CVD associations between central Europe, northern Europe, southern Europe, and the UK were generally small. Men had a slightly higher hazard ratio (HR) in southern Europe (P = 0.043 for overall difference), and those with diabetes had a slightly lower HR in central Europe (P = 0.022 for overall difference) compared with the other regions. Of the six CVD risk factors, minor HR decreases per decade were observed for non-HDL cholesterol [7% per mmol/L; 95% confidence interval (CI), 3-10%] and systolic BP (4% per 20 mmHg; 95% CI, 1-8%), while a minor HR increase per decade was observed for BMI (7% per 10 kg/m2; 95% CI, 1-13%).Conclusion: The results demonstrate that all classic CVD risk factors are still relevant in Europe, irrespective of regional area. Preventive strategies should focus on risk factors with the greatest population attributable risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

Cardiovascular disease
Coronary heart disease
Europe
Risk factor
Stroke

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